3,5-bis(trifluoromethyl)benzoic acid (1S,2R,3R)-3-(tert-butyldimethylsilanyloxymethyl)-2-(4-fluorophenyl)cyclopentyl

Base Information

Chemical Name:3,5-bis(trifluoromethyl)benzoic acid (1S,2R,3R)-3-(tert-butyldimethylsilanyloxymethyl)-2-(4-fluorophenyl)cyclopentyl
CAS No.:912807-20-6
Molecular Formula:C₂₇H₃₁F₇O₃Si
Molecular Weight:564.616
Hs Code.:

Synonyms:3,5-bis(trifluoromethyl)benzoic acid (1S,2R,3R)-3-(tert-butyldimethylsilanyloxymethyl)-2-(4-fluorophenyl)cyclopentyl

Suppliers and Price of 3,5-bis(trifluoromethyl)benzoic acid (1S,2R,3R)-3-(tert-butyldimethylsilanyloxymethyl)-2-(4-fluorophenyl)cyclopentyl

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3,5-bis(trifluoromethyl)benzoic acid (1S,2R,3R)-3-(tert-butyldimethylsilanyloxymethyl)-2-(4-fluorophenyl)cyclopentyl

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3,5-bis(trifluoromethyl)benzoic acid (1S,2R,3R)-3-(tert-butyldimethylsilanyloxymethyl)-2-(4-fluorophenyl)cyclopentyl

There total 5 articles about 3,5-bis(trifluoromethyl)benzoic acid (1S,2R,3R)-3-(tert-butyldimethylsilanyloxymethyl)-2-(4-fluorophenyl)cyclopentyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 405512-97-2
(1S,2R,3R)-3-(tert-butyldimethylsilanyloxymethyl)-2-(4-fluorophenyl)cyclopentanol

: 785-56-8
3,5-bis(trifluoromethyl)phenyl carboxylic acid chloride

: 912807-20-6
3,5-bis(trifluoromethyl)benzoic acid (1S,2R,3R)-3-(tert-butyldimethylsilanyloxymethyl)-2-(4-fluorophenyl)cyclopentyl

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/jo061268x

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 912807-20-6
3,5-bis(trifluoromethyl)benzoic acid (1S,2R,3R)-3-(tert-butyldimethylsilanyloxymethyl)-2-(4-fluorophenyl)cyclopentyl

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / imidazole / dimethylformamide / 18 h / 20 °C

2: 100 percent / Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

With 1H-imidazole; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo061268x

Reference yield:

: 190269-78-4
(1R,2R,3S)-2-(4-fluorophenyl)-3-hydroxycyclopentane-1-carboxylic acid

: 912807-20-6
3,5-bis(trifluoromethyl)benzoic acid (1S,2R,3R)-3-(tert-butyldimethylsilanyloxymethyl)-2-(4-fluorophenyl)cyclopentyl

Guidance literature:: Multi-step reaction with 4 steps

1: HCl / 1 h / Heating

2: 100 percent / LiAlH₄ / tetrahydrofuran / 2 h / 20 °C

3: 74 percent / imidazole / dimethylformamide / 18 h / 20 °C

4: 100 percent / Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

With 1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo061268x