1-(N-(N^α,N^ε-di-Boc-Lys)-N-butylamino)methylbenzene

Base Information

Chemical Name:1-(N-(N^α,N^ε-di-Boc-Lys)-N-butylamino)methylbenzene
CAS No.:1558953-44-8
Molecular Formula:C₂₇H₄₅N₃O₅
Molecular Weight:491.671
Hs Code.:

1-(N-(N<sup>α</sup>,N<sup>ε</sup>-di-Boc-Lys)-N-butylamino)methylbenzene

Synonyms:1-(N-(N^α,N^ε-di-Boc-Lys)-N-butylamino)methylbenzene

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Chemical Property of 1-(N-(N^α,N^ε-di-Boc-Lys)-N-butylamino)methylbenzene

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Technology Process of 1-(N-(N^α,N^ε-di-Boc-Lys)-N-butylamino)methylbenzene

There total 5 articles about 1-(N-(N^α,N^ε-di-Boc-Lys)-N-butylamino)methylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 2483-46-7
Boc-Lys(Boc)-OH

: 18618-49-0
N-butyl-1-aminomethylbenzene hydrochloride

: 1558953-44-8
1-(N-(N^α,N^ε-di-Boc-Lys)-N-butylamino)methylbenzene

Guidance literature:: Boc-Lys(Boc)-OH; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In chloroform; N,N-dimethyl-formamide; at 0 ℃; for 0.0833333h;

N-butyl-1-aminomethylbenzene hydrochloride; In chloroform; N,N-dimethyl-formamide; at 0 - 20 ℃; for 24.5h;
DOI:10.1021/jm401680a

Reference yield:

: 657-27-2,10098-89-2,26124-78-7
L-Lysine hydrochloride

: 1558953-44-8
1-(N-(N^α,N^ε-di-Boc-Lys)-N-butylamino)methylbenzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / water; tetrahydrofuran / 12 h / 0 - 20 °C

1.2: 12 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / chloroform; N,N-dimethyl-formamide / 0.08 h / 0 °C

2.2: 24.5 h / 0 - 20 °C

With sodium hydrogencarbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm401680a

Reference yield:

: 100-52-7
benzaldehyde

: 1558953-44-8
1-(N-(N^α,N^ε-di-Boc-Lys)-N-butylamino)methylbenzene

Guidance literature:: Multi-step reaction with 3 steps

1.1: chloroform; methanol / 6 h / 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate; methanol / 18 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / chloroform; N,N-dimethyl-formamide / 0.08 h / 0 °C

3.2: 24.5 h / 0 - 20 °C

With methanol; sodium tetrahydroborate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm401680a