Technology Process of (E)-methyl 3-(3-(tert-butyl)-5-(4-methoxyphenyl)isoxazol-4-yl)acrylate
There total 4 articles about (E)-methyl 3-(3-(tert-butyl)-5-(4-methoxyphenyl)isoxazol-4-yl)acrylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium(II) trifluoroacetate; tetrabutylammomium bromide; lithium carbonate; copper dichloride;
In
1-methyl-pyrrolidin-2-one;
at 150 ℃;
for 2h;
DOI:10.1021/jo300090k
- Guidance literature:
-
Multi-step reaction with 2 steps
1: pyridine; sodium sulfate / methanol / 20 °C
2: palladium(II) trifluoroacetate; tetrabutylammomium bromide; lithium carbonate; copper dichloride / 1-methyl-pyrrolidin-2-one / 2 h / 150 °C
With
pyridine; palladium(II) trifluoroacetate; tetrabutylammomium bromide; lithium carbonate; sodium sulfate; copper dichloride;
In
1-methyl-pyrrolidin-2-one; methanol;
2: Heck reaction;
DOI:10.1021/jo300090k
- Guidance literature:
-
Multi-step reaction with 3 steps
1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; water; triethylamine / 20 °C / Inert atmosphere
2: pyridine; sodium sulfate / methanol / 20 °C
3: palladium(II) trifluoroacetate; tetrabutylammomium bromide; lithium carbonate; copper dichloride / 1-methyl-pyrrolidin-2-one / 2 h / 150 °C
With
pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium(II) trifluoroacetate; tetrabutylammomium bromide; water; lithium carbonate; sodium sulfate; triethylamine; copper dichloride;
In
1-methyl-pyrrolidin-2-one; methanol;
1: Sonogashira coupling / 3: Heck reaction;
DOI:10.1021/jo300090k
