(S)-3-amino-1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-methylcyclohexyl)pyrrolidin-2-one

Base Information

Chemical Name:(S)-3-amino-1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-methylcyclohexyl)pyrrolidin-2-one
CAS No.:848001-72-9
Molecular Formula:C₁₅H₂₉N₃O
Molecular Weight:267.415
Hs Code.:

Synonyms:(S)-3-amino-1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-methylcyclohexyl)pyrrolidin-2-one

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Chemical Property of (S)-3-amino-1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-methylcyclohexyl)pyrrolidin-2-one

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Technology Process of (S)-3-amino-1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-methylcyclohexyl)pyrrolidin-2-one

There total 7 articles about (S)-3-amino-1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-methylcyclohexyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 848001-70-7
(S)-3-Benzyloxycarbonylamino-1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-methylcyclohexyl)pyrrolidin-2-one

: 848001-72-9
(S)-3-amino-1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-methylcyclohexyl)pyrrolidin-2-one

Guidance literature:: With hydrogen; palladium dihydroxide; In methanol; for 4h; under 760.051 Torr;

Reference yield:

: 420794-44-1
(1S,2R,4R)-4-tert-butoxycarbonylamino-2-methylcyclohexylamine

: 848001-72-9
(S)-3-amino-1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-methylcyclohexyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine; BOP / dichloromethane; N,N-dimethyl-formamide / 12 h / 20 °C

2.1: ethyl acetate / 48 h / 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

5.1: methanol / 0.17 h / 20 °C

5.2: 10 h / 20 °C

6.1: sodium cyanoborohydride / water; methanol / 9 h / 20 °C

7.1: hydrogen bromide; acetic acid / ethyl acetate / 0.42 h / 20 °C

With BOP; hydrogen bromide; sodium cyanoborohydride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ml500505q

Reference yield:

: C₂₅H₃₉N₃O₅S

: 848001-72-9
(S)-3-amino-1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-methylcyclohexyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethyl acetate / 48 h / 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

4.1: methanol / 0.17 h / 20 °C

4.2: 10 h / 20 °C

5.1: sodium cyanoborohydride / water; methanol / 9 h / 20 °C

6.1: hydrogen bromide; acetic acid / ethyl acetate / 0.42 h / 20 °C

With hydrogen bromide; sodium cyanoborohydride; caesium carbonate; acetic acid; trifluoroacetic acid; In methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ml500505q