tert-butyl (1R,3R,4S)-4-((S)-3-benzyloxycarbonylamino-2-oxopyrrolidin-1-yl)-3-methylcyclohexylcarbamate

Base Information

Chemical Name:tert-butyl (1R,3R,4S)-4-((S)-3-benzyloxycarbonylamino-2-oxopyrrolidin-1-yl)-3-methylcyclohexylcarbamate
CAS No.:848001-69-4
Molecular Formula:C₂₄H₃₅N₃O₅
Molecular Weight:445.559
Hs Code.:

Synonyms:tert-butyl (1R,3R,4S)-4-((S)-3-benzyloxycarbonylamino-2-oxopyrrolidin-1-yl)-3-methylcyclohexylcarbamate

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Chemical Property of tert-butyl (1R,3R,4S)-4-((S)-3-benzyloxycarbonylamino-2-oxopyrrolidin-1-yl)-3-methylcyclohexylcarbamate

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Technology Process of tert-butyl (1R,3R,4S)-4-((S)-3-benzyloxycarbonylamino-2-oxopyrrolidin-1-yl)-3-methylcyclohexylcarbamate

There total 5 articles about tert-butyl (1R,3R,4S)-4-((S)-3-benzyloxycarbonylamino-2-oxopyrrolidin-1-yl)-3-methylcyclohexylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 848001-68-3
tert-butyl (1R,3R,4S)-4-((S)-3-benzyloxycarbonylamino-2-oxopyrrolidin-1-yl)-3-(phenylthiomethyl)cyclohexylcarbamate

: 848001-69-4
tert-butyl (1R,3R,4S)-4-((S)-3-benzyloxycarbonylamino-2-oxopyrrolidin-1-yl)-3-methylcyclohexylcarbamate

Guidance literature:: With hydrogen; nickel; In ethanol; water; for 12h; Heating / reflux;

Reference yield:

: C₂₆H₄₂N₃O₅S⁽¹⁺⁾*I^(1-)

: 848001-69-4
tert-butyl (1R,3R,4S)-4-((S)-3-benzyloxycarbonylamino-2-oxopyrrolidin-1-yl)-3-methylcyclohexylcarbamate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/ml500505q

Reference yield:

: 420794-44-1
(1S,2R,4R)-4-tert-butoxycarbonylamino-2-methylcyclohexylamine

: 848001-69-4
tert-butyl (1R,3R,4S)-4-((S)-3-benzyloxycarbonylamino-2-oxopyrrolidin-1-yl)-3-methylcyclohexylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; BOP / dichloromethane; N,N-dimethyl-formamide / 12 h / 20 °C

2: ethyl acetate / 48 h / 20 °C

3: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

With BOP; caesium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ml500505q