(S)-3-Benzyloxycarbonylamino-1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-methylcyclohexyl)pyrrolidin-2-one

Base Information

Chemical Name:(S)-3-Benzyloxycarbonylamino-1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-methylcyclohexyl)pyrrolidin-2-one
CAS No.:848001-70-7
Molecular Formula:C₂₃H₃₅N₃O₃
Molecular Weight:401.549
Hs Code.:

Synonyms:(S)-3-Benzyloxycarbonylamino-1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-methylcyclohexyl)pyrrolidin-2-one

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Chemical Property of (S)-3-Benzyloxycarbonylamino-1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-methylcyclohexyl)pyrrolidin-2-one

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Technology Process of (S)-3-Benzyloxycarbonylamino-1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-methylcyclohexyl)pyrrolidin-2-one

There total 7 articles about (S)-3-Benzyloxycarbonylamino-1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-methylcyclohexyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: C₂₂H₃₃N₃O₃

: 848001-70-7
(S)-3-Benzyloxycarbonylamino-1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-methylcyclohexyl)pyrrolidin-2-one

Guidance literature:: With sodium cyanoborohydride; In methanol; water; at 20 ℃; for 9h;
DOI:10.1021/ml500505q

Reference yield:

: 420794-44-1
(1S,2R,4R)-4-tert-butoxycarbonylamino-2-methylcyclohexylamine

: 848001-70-7
(S)-3-Benzyloxycarbonylamino-1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-methylcyclohexyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine; BOP / dichloromethane; N,N-dimethyl-formamide / 12 h / 20 °C

2.1: ethyl acetate / 48 h / 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

5.1: methanol / 0.17 h / 20 °C

5.2: 10 h / 20 °C

6.1: sodium cyanoborohydride / water; methanol / 9 h / 20 °C

With BOP; sodium cyanoborohydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ml500505q

Reference yield:

: C₂₅H₃₉N₃O₅S

: 848001-70-7
(S)-3-Benzyloxycarbonylamino-1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-methylcyclohexyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethyl acetate / 48 h / 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

4.1: methanol / 0.17 h / 20 °C

4.2: 10 h / 20 °C

5.1: sodium cyanoborohydride / water; methanol / 9 h / 20 °C

With sodium cyanoborohydride; caesium carbonate; trifluoroacetic acid; In methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ml500505q