2-(5-fluoro-2-(4-fluorophenylthio)benzo[b]thiophen-3-yl)ethanamine hydrochloride

Base Information

• Chemical Name: 2-(5-fluoro-2-(4-fluorophenylthio)benzo[b]thiophen-3-yl)ethanamine hydrochloride
• CAS No.: 820975-40-4
• Molecular Formula: C₁₆H₁₃F₂NS₂*ClH
• Molecular Weight: 357.876

Synonyms:2-(5-fluoro-2-(4-fluorophenylthio)benzo[b]thiophen-3-yl)ethanamine hydrochloride

Chemical Property of 2-(5-fluoro-2-(4-fluorophenylthio)benzo[b]thiophen-3-yl)ethanamine hydrochloride

Chemical Property:

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Technology Process of 2-(5-fluoro-2-(4-fluorophenylthio)benzo[b]thiophen-3-yl)ethanamine hydrochloride

There total 1 articles about 2-(5-fluoro-2-(4-fluorophenylthio)benzo[b]thiophen-3-yl)ethanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-(5-fluoro-2-(4-fluorophenylthio)benzo[b]thiophen-3-yl)acetonitrile (820975-39-1) → 2-(5-fluoro-2-(4-fluorophenylthio)benzo[b]thiophen-3-yl)ethanamine hydrochloride (820975-40-4)

Guidance literature:

2-(5-fluoro-2-(4-fluorophenylthio)benzo[b]thiophen-3-yl)acetonitrile; With borane-THF; In tetrahydrofuran; for 3h; Reflux; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; for 1h; Reflux;

DOI:10.1016/j.ejmech.2011.02.044

Reference yield: 92.0%

2-(5-fluoro-2-(4-fluorophenylthio)benzo[b]thiophen-3-yl)ethanamine hydrochloride (820975-40-4) + propionyl chloride (79-03-8) → N-(2-(5-fluoro-2-(4-fluorophenylthio)benzo[b]thiophen-3-yl)ethyl)propionamide (820975-34-6)

Guidance literature:

With potassium carbonate; In dichloromethane; water; at 0 - 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2011.02.044

Reference yield: 71.0%

2-bromoacetyl chloride (22118-09-8) + 2-(5-fluoro-2-(4-fluorophenylthio)benzo[b]thiophen-3-yl)ethanamine hydrochloride (820975-40-4) → N-(2-(5-fluoro-2-(4-fluorophenylthio)benzo[b]thiophen-3-yl)ethyl)bromoacetamide (820975-35-7)

Guidance literature:

With potassium carbonate; In dichloromethane; water; at 0 - 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2011.02.044

upstream raw materials:

2-(5-fluoro-2-(4-fluorophenylthio)benzo[b]thiophen-3-yl)acetonitrile

Downstream raw materials:

N-(2-(5-fluoro-2-(4-fluorophenylthio)benzo[b]thiophen-3-yl)ethyl)bromoacetamide

N-(2-(5-fluoro-2-(4-fluorophenylthio)benzo[b]thiophen-3-yl)ethyl)propionamide

N-(2-(5-fluoro-2-(4-fluorophenylthio)benzo[b]thiophen-3-yl)ethyl)acetamide

N-(2-(5-fluoro-2-(4-fluorophenylthio)benzo[b]thiophen-3-yl)ethyl)acrylamide

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