3-(2-oxo-1-phenethyl-1,2,5,6-tetrahydropyridin-3-yl)propionic acid methyl ester

Base Information

Chemical Name:3-(2-oxo-1-phenethyl-1,2,5,6-tetrahydropyridin-3-yl)propionic acid methyl ester
CAS No.:905970-84-5
Molecular Formula:C₁₇H₂₁NO₃
Molecular Weight:287.359
Hs Code.:

Synonyms:3-(2-oxo-1-phenethyl-1,2,5,6-tetrahydropyridin-3-yl)propionic acid methyl ester

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Chemical Property of 3-(2-oxo-1-phenethyl-1,2,5,6-tetrahydropyridin-3-yl)propionic acid methyl ester

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Technology Process of 3-(2-oxo-1-phenethyl-1,2,5,6-tetrahydropyridin-3-yl)propionic acid methyl ester

There total 6 articles about 3-(2-oxo-1-phenethyl-1,2,5,6-tetrahydropyridin-3-yl)propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 905970-80-1
4-((but-3-enyl)phenethylcarbamoyl)pent-4-enoic acid methyl ester

: 905970-84-5
3-(2-oxo-1-phenethyl-1,2,5,6-tetrahydropyridin-3-yl)propionic acid methyl ester

Guidance literature:: Grubbs catalyst first generation; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/jm0613828

Reference yield:

: 5621-44-3
dimethyl 2-methylenepentanedioate

: 905970-84-5
3-(2-oxo-1-phenethyl-1,2,5,6-tetrahydropyridin-3-yl)propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: camphor-10-sulfonic acid / methanol / 2.5 h / 20 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

3: Grubbs catalyst first generation / dichloromethane / 20 °C / Darkness; Inert atmosphere

With Grubbs catalyst first generation; dmap; camphor-10-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;
DOI:10.1002/cmdc.201300393

Reference yield:

: 93633-32-0
5-methoxy-2-methylene-5-oxopentanoic acid

: 905970-84-5
3-(2-oxo-1-phenethyl-1,2,5,6-tetrahydropyridin-3-yl)propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

2: Grubbs catalyst first generation / dichloromethane / 20 °C / Darkness; Inert atmosphere

With Grubbs catalyst first generation; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1002/cmdc.201300393