4-((but-3-enyl)phenethylcarbamoyl)pent-4-enoic acid methyl ester

Base Information

• Chemical Name: 4-((but-3-enyl)phenethylcarbamoyl)pent-4-enoic acid methyl ester
• CAS No.: 905970-80-1
• Molecular Formula: C₁₉H₂₅NO₃
• Molecular Weight: 315.412
• Mol file: 905970-80-1.mol

Synonyms:4-((but-3-enyl)phenethylcarbamoyl)pent-4-enoic acid methyl ester

Chemical Property of 4-((but-3-enyl)phenethylcarbamoyl)pent-4-enoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-((but-3-enyl)phenethylcarbamoyl)pent-4-enoic acid methyl ester

There total 4 articles about 4-((but-3-enyl)phenethylcarbamoyl)pent-4-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

5-methoxy-2-methylene-5-oxopentanoic acid (93633-32-0) + N-phenethylbut-3-en-1-amine (867324-06-9) → 4-((but-3-enyl)phenethylcarbamoyl)pent-4-enoic acid methyl ester (905970-80-1)

Guidance literature:

With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃; for 8h;

DOI:10.1021/jm0613828

Reference yield:

dimethyl 2-methylenepentanedioate (5621-44-3) → 4-((but-3-enyl)phenethylcarbamoyl)pent-4-enoic acid methyl ester (905970-80-1)

Guidance literature:

Multi-step reaction with 2 steps

1: camphor-10-sulfonic acid / methanol / 2.5 h / 20 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

With dmap; camphor-10-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;

DOI:10.1002/cmdc.201300393

Reference yield:

phenethylamine (64-04-0) → 4-((but-3-enyl)phenethylcarbamoyl)pent-4-enoic acid methyl ester (905970-80-1)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / Heating

2: dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 20 °C

With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/j.bmcl.2006.04.091

upstream raw materials:

5-methoxy-2-methylene-5-oxopentanoic acid

N-phenethylbut-3-en-1-amine

phenethylamine

2-methyleneglutaric acid

Downstream raw materials:

3-(2-oxo-1-phenethyl-1,2,5,6-tetrahydropyridin-3-yl)propionic acid methyl ester