2-(4-{3-[(S)-1-(2,6-dichloro-3-fluorophenyl)ethyl]-1H-pyrrolo[2,3-b]-pyridin-5-yl}pyrazol-1-yl)ethanol

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Chemical Name:2-(4-{3-[(S)-1-(2,6-dichloro-3-fluorophenyl)ethyl]-1H-pyrrolo[2,3-b]-pyridin-5-yl}pyrazol-1-yl)ethanol
CAS No.:1227611-60-0
Molecular Formula:C₂₀H₁₇Cl₂FN₄O
Molecular Weight:419.286
Hs Code.:

Synonyms:2-(4-{3-[(S)-1-(2,6-dichloro-3-fluorophenyl)ethyl]-1H-pyrrolo[2,3-b]-pyridin-5-yl}pyrazol-1-yl)ethanol

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Chemical Property of 2-(4-{3-[(S)-1-(2,6-dichloro-3-fluorophenyl)ethyl]-1H-pyrrolo[2,3-b]-pyridin-5-yl}pyrazol-1-yl)ethanol

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Technology Process of 2-(4-{3-[(S)-1-(2,6-dichloro-3-fluorophenyl)ethyl]-1H-pyrrolo[2,3-b]-pyridin-5-yl}pyrazol-1-yl)ethanol

There total 8 articles about 2-(4-{3-[(S)-1-(2,6-dichloro-3-fluorophenyl)ethyl]-1H-pyrrolo[2,3-b]-pyridin-5-yl}pyrazol-1-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 956907-34-9
1-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1227611-86-0
((S)-1-{5-bromo-3-[(S)-1-(2,6-dichloro-3-fluorophenyl)ethyl]pyrrolo[2,3-b]pyridine-1-carbonyl}-3-methylbutyl)carbamic acid 9H-fluoren-9-ylmethyl ester

: 1227611-60-0
2-(4-{3-[(S)-1-(2,6-dichloro-3-fluorophenyl)ethyl]-1H-pyrrolo[2,3-b]-pyridin-5-yl}pyrazol-1-yl)ethanol

Guidance literature:: 1-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; ((S)-1-{5-bromo-3-[(S)-1-(2,6-dichloro-3-fluorophenyl)ethyl]pyrrolo[2,3-b]pyridine-1-carbonyl}-3-methylbutyl)carbamic acid 9H-fluoren-9-ylmethyl ester; With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 85 ℃; for 1h;

With hydrogenchloride; water; In 1,4-dioxane; at 20 ℃; for 1h;

With ammonia; In methanol; dichloromethane;

Reference yield:

: C₂₀H₁₇Cl₂FN₄O

: 1227611-60-0
2-(4-{3-[(S)-1-(2,6-dichloro-3-fluorophenyl)ethyl]-1H-pyrrolo[2,3-b]-pyridin-5-yl}pyrazol-1-yl)ethanol

: C₂₀H₁₇Cl₂FN₄O

Guidance literature:: With ammonium hydroxide; In ethanol; Resolution of racemate; Supercritical conditions;

Reference yield:

: 1435-48-9
1,3-dichloro-4-fluorobenzene

: 1227611-60-0
2-(4-{3-[(S)-1-(2,6-dichloro-3-fluorophenyl)ethyl]-1H-pyrrolo[2,3-b]-pyridin-5-yl}pyrazol-1-yl)ethanol

: C₂₀H₁₇Cl₂FN₄O

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 16 h / 10 - 15 °C / Inert atmosphere

2.1: tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

3.1: trifluorormethanesulfonic acid / dichloromethane / 16 h / 10 - 20 °C / Inert atmosphere

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 0.5 h / 100 °C / Inert atmosphere; Microwave irradiation

5.1: hydrogenchloride / methanol; ethyl acetate / 16 h / 20 °C / Inert atmosphere

6.1: ammonium hydroxide / ethanol / Resolution of racemate; Supercritical conditions

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; ammonium hydroxide; n-butyllithium; trifluorormethanesulfonic acid; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate;