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1435-48-9

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1435-48-9 Usage

Chemical Properties

Clear colourless to yellow liquid

Check Digit Verification of cas no

The CAS Registry Mumber 1435-48-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,3 and 5 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1435-48:
(6*1)+(5*4)+(4*3)+(3*5)+(2*4)+(1*8)=69
69 % 10 = 9
So 1435-48-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H3Cl2F/c7-4-1-2-6(9)5(8)3-4/h1-3H

1435-48-9 Well-known Company Product Price

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  • Alfa Aesar

  • (A17953)  1,3-Dichloro-4-fluorobenzene, 99%   

  • 1435-48-9

  • 10g

  • 236.0CNY

  • Detail
  • Alfa Aesar

  • (A17953)  1,3-Dichloro-4-fluorobenzene, 99%   

  • 1435-48-9

  • 50g

  • 618.0CNY

  • Detail
  • Alfa Aesar

  • (A17953)  1,3-Dichloro-4-fluorobenzene, 99%   

  • 1435-48-9

  • 250g

  • 2621.0CNY

  • Detail

1435-48-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,3-Dichloro-4-fluorobenzene

1.2 Other means of identification

Product number -
Other names 1,3-DICHLOROFLUOROBENZENE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1435-48-9 SDS

1435-48-9Synthetic route

2,4-Dichloroaniline
554-00-7

2,4-Dichloroaniline

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
Stage #1: 2,4-Dichloroaniline With hydrogenchloride; fluoroboric acid; sodium nitrite In water at 25℃; for 0.00555556h; Balz-Schiemann Reaction;
Stage #2: In 1,2-dichloro-benzene at 190℃; for 0.0166667h; Balz-Schiemann Reaction;
93%
Stage #1: 2,4-Dichloroaniline With sodium tetrafluoroborate; sodium nitrite acidic conditions;
Stage #2: at 150 - 170℃; Schieman reaction; Further stages.;
1,2,4-Trichlorobenzene
120-82-1

1,2,4-Trichlorobenzene

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
With potassium fluoride; 5,11,17,23,29,35-hexakis(tert-butyl)-37,38,39,40,41-hexakis(hydroxy)calix[6]arene In sulfolane at 185℃; for 5h; Reagent/catalyst; Temperature; Inert atmosphere; Sealed tube;92%
3-chloro-4-fluoronitrobenzene
350-30-1

3-chloro-4-fluoronitrobenzene

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
With chlorine at 170 - 180℃; for 8h; Temperature;91.7%
Multi-step reaction with 2 steps
1: titanium (III)-chloride; water
2: aqueous HCl / Diazotization.Erwaermen der Diazoniumsalz-Loesung mit CuCl
View Scheme
2,4-dichloroaniline hydrochloride
29084-76-2

2,4-dichloroaniline hydrochloride

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
Stage #1: 2,4-dichloroaniline hydrochloride With hydrogenchloride at -5℃;
Stage #2: With tetrafluoroboric acid; sodium nitrite In water at 0℃; for 0.0833333h;
50.1%
3-chloro-4-fluorophenylamine
367-21-5

3-chloro-4-fluorophenylamine

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
With hydrogenchloride Diazotization.Erwaermen der Diazoniumsalz-Loesung mit CuCl;
2,4-Dinitrofluorobenzene
70-34-8

2,4-Dinitrofluorobenzene

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
With chlorine at 200℃;
2,3-dichlorofluorobenzene
36556-50-0

2,3-dichlorofluorobenzene

A

3,4-dichlorofluorobenzene
1435-49-0

3,4-dichlorofluorobenzene

B

3-chlorofluorobenzene
625-98-9

3-chlorofluorobenzene

C

1,4-dichloro-2-fluorobenzene
348-59-4

1,4-dichloro-2-fluorobenzene

D

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
In acetonitrile for 10h; Product distribution; Irradiation;A 5 % Chromat.
B 5 % Chromat.
C 13 % Chromat.
D 1 % Chromat.
2,4-dichlorophenylboronic acid
68716-47-2

2,4-dichlorophenylboronic acid

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
With cesium fluoroxysulphate In methanol at -10℃; for 24h;28 % Spectr.
(N-B)-Perhydro-2-(2,4-dichlorophenyl)-6-methyl-1,3-dioxa-6-aza-2-boracine

(N-B)-Perhydro-2-(2,4-dichlorophenyl)-6-methyl-1,3-dioxa-6-aza-2-boracine

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
With meta-dinitrobenzene; cesium fluoroxysulphate In acetonitrile Ambient temperature;40 % Spectr.
fluorobenzene
462-06-6

fluorobenzene

iron-powder

iron-powder

A

3,4-dichlorofluorobenzene
1435-49-0

3,4-dichlorofluorobenzene

B

1-Chloro-4-fluorobenzene
352-33-0

1-Chloro-4-fluorobenzene

C

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
Einleiten von 2 Mol Chlor;
2.4-dichloro-benzodiazonium-(1)-tetrafluoroborate

2.4-dichloro-benzodiazonium-(1)-tetrafluoroborate

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
Thermolysis;
4-Fluoronitrobenzene
350-46-9

4-Fluoronitrobenzene

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: iron-powder / Einleiten von Chlor
2: titanium (III)-chloride; water
3: aqueous HCl / Diazotization.Erwaermen der Diazoniumsalz-Loesung mit CuCl
View Scheme
1,2-dichloro-benzene
95-50-1

1,2-dichloro-benzene

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: nitric acid; sulfuric acid / 2 h / 95 - 100 °C
2.1: potassium fluoride / 3 h / 140 - 150 °C
2.2: 7 h / 165 - 170 °C
3.1: chlorine / 8 h / 170 - 180 °C
View Scheme
3,4-dichloronitrobenzene
99-54-7

3,4-dichloronitrobenzene

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium fluoride / 3 h / 140 - 150 °C
1.2: 7 h / 165 - 170 °C
2.1: chlorine / 8 h / 170 - 180 °C
View Scheme
C13H4Cl4F2O

C13H4Cl4F2O

A

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

B

C7H2Cl2FO2(1-)*Na(1+)

C7H2Cl2FO2(1-)*Na(1+)

Conditions
ConditionsYield
Stage #1: C13H4Cl4F2O With sodium hydroxide at 90 - 100℃; for 1h;
Stage #2: In 1,4-dioxane at 110 - 150℃; for 3h;
C13H4Cl4F2O

C13H4Cl4F2O

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

Conditions
ConditionsYield
With sodium hydroxide at 140 - 150℃; Temperature;
1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

2,4-dichloro-5-fluoronitrobenzene
2105-59-1

2,4-dichloro-5-fluoronitrobenzene

Conditions
ConditionsYield
With sulfuric acid; nitric acid at 50℃; for 2h; Temperature;99.3%
With sulfuric acid; nitric acid at 50 - 60℃; for 3h;98%
With sulfuric acid; potassium nitrate at 0 - 20℃; for 12h;97%
With sulfuric acid; nitric acid
With sulfuric acid; sulfur trioxide; nitric acid
1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

2,6-dichloro-3-fluorobenzenethiol

2,6-dichloro-3-fluorobenzenethiol

Conditions
ConditionsYield
Stage #1: 1,3-dichloro-4-fluorobenzene With n-butyllithium In tetrahydrofuran at -78℃; for 1.5h; Inert atmosphere;
Stage #2: With sulfur In tetrahydrofuran at -78℃; for 2h; Inert atmosphere;
99%
carbon dioxide
124-38-9

carbon dioxide

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

2,4-dichloro-5-fluorobenzoyl chloride
86393-34-2

2,4-dichloro-5-fluorobenzoyl chloride

Conditions
ConditionsYield
With Cationic resin catalyst In tetrachloromethane at 40 - 60℃; under 15001.5 Torr; for 5h; Pressure; Temperature; Reagent/catalyst;98.8%
tetrachloromethane
56-23-5

tetrachloromethane

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

1,5-dichloro-2-fluoro-4-(trichloromethyl)benzene

1,5-dichloro-2-fluoro-4-(trichloromethyl)benzene

Conditions
ConditionsYield
With aluminum (III) chloride at 40℃; for 4h; Temperature;95.2%
With phosphotungstic acid supported on magnetic ZrO2 for 0.5h; Autoclave; Reflux;94%
1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

2-(3,5-dichloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-(3,5-dichloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Conditions
ConditionsYield
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine In tetrahydrofuran at 80℃; for 6h; Inert atmosphere;94%
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine In tetrahydrofuran at 80℃; for 18h; Inert atmosphere;
With (1,5-cyclooctadiene)(methoxy)iridium(l) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine In tetrahydrofuran at 80℃; for 24h; Inert atmosphere;
methanol
67-56-1

methanol

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

1,3-dichloro-4-methoxybenzene
553-82-2

1,3-dichloro-4-methoxybenzene

Conditions
ConditionsYield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In 2,2,2-trifluoroethanol; 1,2-dichloro-ethane at 40℃; for 48h; Reagent/catalyst; Solvent; Irradiation;94%
4-(3-((4-chloro-7-methoxyquinazolin-6-yl)oxy)propyl)morpholine
320366-66-3

4-(3-((4-chloro-7-methoxyquinazolin-6-yl)oxy)propyl)morpholine

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

gefitinib
184475-35-2

gefitinib

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide Reflux;91%
1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

acetyl chloride
75-36-5

acetyl chloride

2,4-dichloro-5-fluoroacetophenone
704-10-9

2,4-dichloro-5-fluoroacetophenone

Conditions
ConditionsYield
With aluminum (III) chloride at 110℃; Reagent/catalyst; Temperature;89.3%
With aluminum (III) chloride Friedel Crafts acylation;52%
With aluminum (III) chloride at 30 - 120℃; Product distribution / selectivity;
aluminum (III) chloride
1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

isopropyl alcohol
67-63-0

isopropyl alcohol

2,4-dichloro-1-isopropoxybenzene
6851-40-7

2,4-dichloro-1-isopropoxybenzene

Conditions
ConditionsYield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In 2,2,2-trifluoroethanol; 1,2-dichloro-ethane at 40℃; for 48h; Irradiation;89%
ethanol
64-17-5

ethanol

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

2,4-dichloro-1-ethoxybenzene
5392-86-9

2,4-dichloro-1-ethoxybenzene

Conditions
ConditionsYield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In 2,2,2-trifluoroethanol; 1,2-dichloro-ethane at 40℃; for 48h; Irradiation;87%
Cyclopropylmethanol
2516-33-8

Cyclopropylmethanol

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

2,4-dichloro-1-(cyclopropylmethoxy)benzene

2,4-dichloro-1-(cyclopropylmethoxy)benzene

Conditions
ConditionsYield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In 2,2,2-trifluoroethanol; 1,2-dichloro-ethane at 40℃; for 48h; Irradiation;87%
o-cyanobromobenzene
2042-37-7

o-cyanobromobenzene

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

5’-chloro-2’-fluoro-[1,1’-biphenyl]-2-carbonitrile

5’-chloro-2’-fluoro-[1,1’-biphenyl]-2-carbonitrile

Conditions
ConditionsYield
With potassium pivalate; palladium dichloride In N,N-dimethyl acetamide at 150℃; for 16h; regioselective reaction;86%
tetrachloromethane
56-23-5

tetrachloromethane

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

2,4-dichloro-5-fluorobenzoyl chloride
86393-34-2

2,4-dichloro-5-fluorobenzoyl chloride

Conditions
ConditionsYield
Stage #1: tetrachloromethane; 1,3-dichloro-4-fluorobenzene for 0.5h; Autoclave; Reflux;
Stage #2: With water at 20 - 40℃; for 1h; Reagent/catalyst;
86%
Methyl formate
107-31-3

Methyl formate

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

2,6-dichloro-3-fluorobenzaldehyde

2,6-dichloro-3-fluorobenzaldehyde

Conditions
ConditionsYield
Stage #1: 1,3-dichloro-4-fluorobenzene With n-butyllithium In tetrahydrofuran at -78℃; for 1h; Inert atmosphere;
Stage #2: Methyl formate In tetrahydrofuran at 10 - 15℃; for 16h; Inert atmosphere;
85.49%
Stage #1: 1,3-dichloro-4-fluorobenzene With n-butyllithium In tetrahydrofuran; hexanes at -78 - -70℃; for 2h; Inert atmosphere;
Stage #2: Methyl formate In tetrahydrofuran; hexanes at -78℃; Inert atmosphere;
Stage #3: With water; ammonium chloride In tetrahydrofuran; hexanes at 20℃; Inert atmosphere;
Stage #1: 1,3-dichloro-4-fluorobenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1.5h; Inert atmosphere;
Stage #2: Methyl formate In tetrahydrofuran; hexane at -78 - 20℃; Inert atmosphere;
Stage #3: With ammonium chloride In tetrahydrofuran; hexane; water
3,5-dimethoxyphenol
500-99-2

3,5-dimethoxyphenol

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

2,4-dichloro-1-(3,5-dimethoxyphenoxy)benzene
1379803-44-7

2,4-dichloro-1-(3,5-dimethoxyphenoxy)benzene

Conditions
ConditionsYield
Stage #1: 3,5-dimethoxyphenol With caesium carbonate In 1-methyl-pyrrolidin-2-one at 50℃; for 0.5h; Inert atmosphere;
Stage #2: 1,3-dichloro-4-fluorobenzene In 1-methyl-pyrrolidin-2-one at 120℃; for 2h; Inert atmosphere;
84%
1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

1-(Trimethylsilyl)imidazole
18156-74-6

1-(Trimethylsilyl)imidazole

A

trimethylsilyl fluoride
420-56-4

trimethylsilyl fluoride

B

1-(2,4-dichlorophenyl)-1H-imidazole
190199-40-7

1-(2,4-dichlorophenyl)-1H-imidazole

Conditions
ConditionsYield
With cesium fluoride In N,N-dimethyl-formamide at 60℃; for 20h; Inert atmosphere;A n/a
B 80%
ethyl acetohydroximate
10576-12-2

ethyl acetohydroximate

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

N-(2,4-Dichloro-phenoxy)-acetimidic acid ethyl ester

N-(2,4-Dichloro-phenoxy)-acetimidic acid ethyl ester

Conditions
ConditionsYield
With potassium tert-butylate In N,N-dimethyl-formamide 1.) r.t., 30 min, 2.) 80 deg C, 1.5 h;77.8%
tetrachloromethane
56-23-5

tetrachloromethane

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

A

1,5-dichloro-2-fluoro-4-(trichloromethyl)benzene

1,5-dichloro-2-fluoro-4-(trichloromethyl)benzene

B

dichloro-bis(2,4-dichloro-5-fluorophenyl)methane

dichloro-bis(2,4-dichloro-5-fluorophenyl)methane

Conditions
ConditionsYield
at 40℃; for 2h; Temperature;A 76.6%
B 22.6%
With iron(III) chloride at 70℃; for 2h;A 75.1%
B 20.3%
With aluminum (III) chloride at 40℃; for 8h;A 3.2 g
B 13.5 g
With aluminum (III) chloride at 40℃; for 8h;
oxirane
75-21-8

oxirane

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

2-(2,6-dichloro-3-fluorophenyl)ethanol

2-(2,6-dichloro-3-fluorophenyl)ethanol

Conditions
ConditionsYield
Stage #1: 1,3-dichloro-4-fluorobenzene With n-butyllithium In tetrahydrofuran at -78℃; for 1h; Inert atmosphere;
Stage #2: oxirane In tetrahydrofuran at -78℃; for 2h; Inert atmosphere;
75%
Stage #1: 1,3-dichloro-4-fluorobenzene With n-butyllithium In tetrahydrofuran at -78℃; for 1h;
Stage #2: oxirane In tetrahydrofuran at -78℃; for 2h;
75%
3-bromoquinoline
5332-24-1

3-bromoquinoline

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

A

3-(3,5-dichloro-2-fluorophenyl)quinoline

3-(3,5-dichloro-2-fluorophenyl)quinoline

B

C15H8Cl2FN

C15H8Cl2FN

C

C15H8Cl2FN

C15H8Cl2FN

Conditions
ConditionsYield
With potassium pivalate; palladium dichloride In N,N-dimethyl acetamide at 150℃; for 16h; regioselective reaction;A 72%
B n/a
C n/a
(R)-4-(benzyl-methyl-amino)-1-tert-butoxy-butan-2-ol
865864-47-7

(R)-4-(benzyl-methyl-amino)-1-tert-butoxy-butan-2-ol

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

(R)-benzyl-[4-tert-butoxy-3-(2,4-dichloro-phenoxy)-butyl]-methyl amine
865865-21-0

(R)-benzyl-[4-tert-butoxy-3-(2,4-dichloro-phenoxy)-butyl]-methyl amine

Conditions
ConditionsYield
Stage #1: (R)-4-(benzyl-methyl-amino)-1-tert-butoxy-butan-2-ol With sodium hydride In dimethyl sulfoxide for 0.5h;
Stage #2: 1,3-dichloro-4-fluorobenzene In dimethyl sulfoxide
71%
1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

1-(Trimethylsilyl)imidazole
18156-74-6

1-(Trimethylsilyl)imidazole

1-(2,4-dichlorophenyl)-1H-imidazole
190199-40-7

1-(2,4-dichlorophenyl)-1H-imidazole

Conditions
ConditionsYield
With copper(l) iodide In methanol; N,N-dimethyl-formamide at 100℃; Inert atmosphere;70%
1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

2,4-dichloro-5-fluoro-benzoic acid
86522-89-6

2,4-dichloro-5-fluoro-benzoic acid

Conditions
ConditionsYield
66%
Multi-step reaction with 3 steps
1: 2 h / 40 °C
2: iron(III) chloride; water / 90 °C
3: potassium perchlorate / N,N-dimethyl-formamide / Reflux
View Scheme
4-bromobenzenecarbonitrile
623-00-7

4-bromobenzenecarbonitrile

1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

A

C13H6Cl2FN

C13H6Cl2FN

B

C13H6Cl2FN

C13H6Cl2FN

C

3’,5’-dichloro-2’-fluoro-[1,1’-biphenyl]-4-carbonitrile

3’,5’-dichloro-2’-fluoro-[1,1’-biphenyl]-4-carbonitrile

Conditions
ConditionsYield
With potassium pivalate; palladium dichloride In N,N-dimethyl acetamide at 150℃; for 16h; regioselective reaction;A n/a
B n/a
C 66%
1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

4-bromo-benzaldehyde
1122-91-4

4-bromo-benzaldehyde

A

C13H7Cl2FO

C13H7Cl2FO

B

C13H7Cl2FO

C13H7Cl2FO

C

3’,5’-dichloro-2’-fluoro-[1,1’-biphenyl]-4-carbaldehyde

3’,5’-dichloro-2’-fluoro-[1,1’-biphenyl]-4-carbaldehyde

Conditions
ConditionsYield
With potassium pivalate; palladium dichloride In N,N-dimethyl acetamide at 150℃; for 16h; regioselective reaction;A n/a
B n/a
C 66%
1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

cyclohexanol
108-93-0

cyclohexanol

2,4-dichloro-1-(cyclohexyloxy)benzene

2,4-dichloro-1-(cyclohexyloxy)benzene

Conditions
ConditionsYield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In 2,2,2-trifluoroethanol; 1,2-dichloro-ethane at 40℃; for 48h; Irradiation;64%
1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

C6H2Cl3FO2S

C6H2Cl3FO2S

Conditions
ConditionsYield
With chlorosulfonic acid at 100℃; for 12h;63%

1435-48-9Relevant articles and documents

Environment-friendly production process of 2, 4-dichloro-5-fluorobenzoyl chloride

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Paragraph 0063-0068, (2020/08/22)

The present invention relates to the field of chemistry, and particularly provides a preparation method of 2, 4-dichloro-5-fluorobenzoyl chloride. According to the invention, dimerization by-productsof the 2, 4-dichloro-5-fluorobenzoyl chloride produced by a carbon tetrachloride method are subjected to alkaline hydrolysis under the action of a catalyst, then after acidification, the processed product reacts with trichloride generated by condensation of a main reaction to be converted into 2, 4-dichloro-5-fluorobenzoyl chloride, and the yield reaches over 99.8%.

Synthesis method of 2, 4-dichlorofluorobenzene

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Paragraph 0030-0033, (2019/07/04)

The invention discloses a synthetic method of 2, 4-dichlorofluorobenzene. The method comprises the following steps: 1,2,4-trichlorobenzene is used as a raw material, a calix[6]arene and trimethylolpropane borate compound is used as a phase transfer catalyst, spray-dried potassium fluoride is used as a fluorinating agent, and the 2,4-dichlorofluorobenzene is produced through one step of reaction; herein, the molar ratio of trimethylolpropane borate to potassium fluoride is 1:10-1:20, preferably 1:15; the molar ratio of the potassium fluoride to the 1,2,4-trichlorobenzene is 1:1.1; the calix[6]arene is p-tert-butyl calix[6]arene; and the molar ratio of the p-tert-butyl calix[6]arene to the 1,2,4-trichlorobenzene is 0.001:1-0.05:1, preferably 0.02:1. By using the calixarene and trihydroxymethyl borate composite catalyst, the catalytic efficiency is greatly improved, and the product yield is as high as 92%. The boiling point of the 2,4-dichlorofluorobenzene is 168-169 DEG C, the boiling point of the raw material 1,2,4-trichlorobenzene is 214 DEG C, and the boiling point of the solvent sulfolane is 285 DEG C, so that the product is simple to separate and purify. The method has the advantages of one-step synthesis, short reaction route, avoidance of nitrification and high-temperature chlorination, safer synthesis process and suitability for industrial production.

O-dichlorobenzene with a quinolone drugs for coproduction method of key intermediate

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Paragraph 0020; 0075-0076, (2017/01/19)

The invention relates to the field of methods for preparing medicinal intermediates, in particular to the field of methods for preparing key intermediates of quinolone medicines, and develops a method for coproducing the key intermediates of the quinolone medicines by using o-dichlorobenzene as a raw material. The method comprises the following steps of: nitrifying the o-dichlorobenzene serving as the raw material, and performing distillation, purification and stepwise crystallization to obtain 2,3-dichloronitrobenzene and 3,4-dichloronitrobenzene; performing fluoridation on the 2,3-dichloronitrobenzene to obtain 3-chloro-2-fluoronitrobenzene, performing chlorination to obtain 2,6-dichlorofluorobenzene, performing nitration to obtain 1,3-dichloro-2-fluoro-4-nitrobenzene, and finally performing fluoridation to obtain 2,3,4-trifluoronitrobenzene; and performing fluoridation on the 2,3,4-trifluoronitrobenzene to obtain 3-chloro-4-fluoronitrobenzene, performing chlorination to obtain 1,3-dichloro-4-fluorobenzene, and finally performing acylation reaction on the 1,3-dichloro-4-fluorobenzene and acetylchloride to obtain 2,4-dichloro-5-fluoroacetophenone.

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