1435-48-9Relevant articles and documents
Environment-friendly production process of 2, 4-dichloro-5-fluorobenzoyl chloride
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Paragraph 0063-0068, (2020/08/22)
The present invention relates to the field of chemistry, and particularly provides a preparation method of 2, 4-dichloro-5-fluorobenzoyl chloride. According to the invention, dimerization by-productsof the 2, 4-dichloro-5-fluorobenzoyl chloride produced by a carbon tetrachloride method are subjected to alkaline hydrolysis under the action of a catalyst, then after acidification, the processed product reacts with trichloride generated by condensation of a main reaction to be converted into 2, 4-dichloro-5-fluorobenzoyl chloride, and the yield reaches over 99.8%.
Preparation method for fluoroquinolones intermediate 2,4-dichloro-5-fluorobenzoyl chloride
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Paragraph 0054; 0055; 0057; 0058; 0060; 0061, (2019/05/20)
The invention discloses a preparation method for fluoroquinolones intermediate 2,4-dichloro-5-fluorobenzoyl chloride, and belongs to the technical field of the pharmaceutical synthesis. Through changing a compound IV into a compound V* and raw material 2,4-dichlor fluorbenzene, easy explosive materials of hydrogen peroxide and the like are avoided from being used. The compound V*, through a one-step reaction, is changed into the compound 2,4-dichloro-5-fluorobenzoyl chloride. A synthesized product is higher in purity, a total yield of a two-step reaction is higher, the generated starting raw material 2,4-dichlor fluorbenzene can be recycled, and carboxylate (V*) is changed into acyl chloride (II), and hydrochloric acid is not generated, pollution can be reduced. The method is more superiorto an existing technology, capable of increasing a resource utilization rate, reducing a production risk, reducing production cost, and more suitable for industrial production.
O-dichlorobenzene with a quinolone drugs for coproduction method of key intermediate
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, (2017/01/19)
The invention relates to the field of methods for preparing medicinal intermediates, in particular to the field of methods for preparing key intermediates of quinolone medicines, and develops a method for coproducing the key intermediates of the quinolone medicines by using o-dichlorobenzene as a raw material. The method comprises the following steps of: nitrifying the o-dichlorobenzene serving as the raw material, and performing distillation, purification and stepwise crystallization to obtain 2,3-dichloronitrobenzene and 3,4-dichloronitrobenzene; performing fluoridation on the 2,3-dichloronitrobenzene to obtain 3-chloro-2-fluoronitrobenzene, performing chlorination to obtain 2,6-dichlorofluorobenzene, performing nitration to obtain 1,3-dichloro-2-fluoro-4-nitrobenzene, and finally performing fluoridation to obtain 2,3,4-trifluoronitrobenzene; and performing fluoridation on the 2,3,4-trifluoronitrobenzene to obtain 3-chloro-4-fluoronitrobenzene, performing chlorination to obtain 1,3-dichloro-4-fluorobenzene, and finally performing acylation reaction on the 1,3-dichloro-4-fluorobenzene and acetylchloride to obtain 2,4-dichloro-5-fluoroacetophenone.