(R)-4-(Benzyl-hydroxy-amino)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-2-ynoic acid methyl ester

Base Information

Chemical Name:(R)-4-(Benzyl-hydroxy-amino)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-2-ynoic acid methyl ester
CAS No.:210415-78-4
Molecular Formula:C₁₇H₂₁NO₅
Molecular Weight:319.357
Hs Code.:

Synonyms:(R)-4-(Benzyl-hydroxy-amino)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-2-ynoic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-(Benzyl-hydroxy-amino)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-2-ynoic acid methyl ester

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Technology Process of (R)-4-(Benzyl-hydroxy-amino)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-2-ynoic acid methyl ester

There total 2 articles about (R)-4-(Benzyl-hydroxy-amino)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-2-ynoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 91190-38-4,111058-38-9,1165677-00-8
N-benzyl-2,3-O-isopropylidene-D-glyceraldehyde nitrone

: 922-67-8
propynoic acid methyl ester

: 210415-78-4
(R)-4-(Benzyl-hydroxy-amino)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-2-ynoic acid methyl ester

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction; 1.) THF, hexane, -80 deg C, 15 min, 2.) THF, hexane, -80 deg C, 15 min;
DOI:10.1016/S0957-4166(98)00150-5

Reference yield:

: 91190-38-4,111058-38-9,1165677-00-8
N-benzyl-2,3-O-isopropylidene-D-glyceraldehyde nitrone

: 922-67-8
propynoic acid methyl ester

: 210415-79-5
(S)-4-(Benzyl-hydroxy-amino)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-2-ynoic acid methyl ester

: 210415-78-4
(R)-4-(Benzyl-hydroxy-amino)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-2-ynoic acid methyl ester

Guidance literature:: With n-butyllithium; diethylaluminium chloride; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, hexane, -80 deg C, 15 min, 2.) THF, hexane, Et₂O, -80 deg C, 1 h;
DOI:10.1016/S0957-4166(98)00150-5

Reference yield: 100.0%

: 210415-78-4
(R)-4-(Benzyl-hydroxy-amino)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-2-ynoic acid methyl ester

: 210415-80-8
(Z)-(R)-4-(Benzyl-hydroxy-amino)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-2-enoic acid methyl ester

Guidance literature:: With hydrogen; Lindlar's catalyst; In ethyl acetate; for 0.75h; under 735.5 Torr; Ambient temperature;
DOI:10.1016/S0957-4166(98)00150-5