(E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate

Base Information

• Chemical Name: (E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate
• CAS No.: 1292309-90-0
• Molecular Formula: C₂₇H₃₈N₂O₇
• Molecular Weight: 502.608
• Mol file: 1292309-90-0.mol

Synonyms:(E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate

Chemical Property of (E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate

There total 7 articles about (E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-N-(tert-butyloxycarbonyl)-4-N-methylaminostyrene (937183-61-4) + 2-(2-(2-(2-(5-iodopyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethanol (1346502-37-1) → (E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate (1292309-90-0)

Guidance literature:

With tetrabutylammomium bromide; palladium diacetate; potassium carbonate; In N,N-dimethyl-formamide; at 65 ℃; Inert atmosphere;

DOI:10.1021/jm2009106

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate (1292309-90-0)

Guidance literature:

Multi-step reaction with 3 steps

1: water / 4 h / 35 °C

2: sodium hydride / N,N-dimethyl-formamide / 6 h / 20 °C

3: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 65 °C / Inert atmosphere

With tetrabutylammomium bromide; palladium diacetate; sodium hydride; potassium carbonate; In water; N,N-dimethyl-formamide;

DOI:10.1021/jm2009106

Reference yield:

4-vinyl benzylamine (1520-21-4,25086-42-4) → (E)-tert-butyl 4-(2-(6-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl(methyl)carbamate (1292309-90-0)

Guidance literature:

Multi-step reaction with 3 steps

1: water / 4 h / 35 °C

2: sodium hydride / N,N-dimethyl-formamide / 6 h / 20 °C

3: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 65 °C / Inert atmosphere

With tetrabutylammomium bromide; palladium diacetate; sodium hydride; potassium carbonate; In water; N,N-dimethyl-formamide;

DOI:10.1021/jm2009106

upstream raw materials:

2-choro-5-iodopyridine

4-N-(tert-butyloxycarbonyl)-4-N-methylaminostyrene

2-(2-(2-(2-(5-iodopyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethanol

Tetraethylene glycol

Downstream raw materials:

2-(1,3-di((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)propan-2-yloxy)tetrahydro-2H-pyran

2-(1,3-di((E)-2-(2-(2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)propan-2-yloxy)tetrahydro-2H-pyran

1,3-di((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)propan-2-ol

1,3-di((E)-2-(2-(2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)propan-2-ol