AZ 7550

Base Information

Chemical Name:AZ 7550
CAS No.:1421373-99-0
Molecular Formula:C₂₇H₃₁N₇O₂
Molecular Weight:485.589
Hs Code.:
Mol file:1421373-99-0.mol

Synonyms:Ν-(4-methoxy-2-(methyl(2-(methylamino)ethyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide

Suppliers and Price of AZ 7550

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
AZ7550
25mg
$ 1540.00

Total 8 raw suppliers

Chemical Property of AZ 7550

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

AZ7550 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses AZ7550 is an impurity of the drug Osimertinib. Osimertinib is a selective EGFR inhibitor (epidermal growth factor receptor), used in the treatments of nonsmall-cell lung cancer (NSCLC).

Technology Process of AZ 7550

There total 10 articles about AZ 7550 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.1%

: 1421373-33-2
tert-butyl N-[2-[[5-methoxy-4-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-(prop-2-enoylamino)phenyl](methyl)amino]ethyl]-N-methylcarbamate

: 1421373-99-0
Ν-(4-methoxy-2-(methyl(2-(methylamino)ethyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 3h;

Reference yield:

: 1421372-94-2
N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indole-3-yl)-pyrimidine-2-amine

: 1421373-99-0
Ν-(4-methoxy-2-(methyl(2-(methylamino)ethyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 4 h / 100 °C / Microwave irradiation

2: iron; ammonium chloride / water; ethanol / 1.5 h / Reflux

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.58 h / Cooling

4: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl acetamide; water;

Reference yield:

: 1421373-35-4
tert-butyl (2-((5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-nitrophenyl)(methyl)amino)ethyl)(methyl)carbamate

: 1421373-99-0
Ν-(4-methoxy-2-(methyl(2-(methylamino)ethyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: iron; ammonium chloride / water; ethanol / 1.5 h / Reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.58 h / Cooling

3: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; water;