tert-butyl N-[2-[[5-methoxy-4-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-(prop-2-enoylamino)phenyl](methyl)amino]ethyl]-N-methylcarbamate

Base Information

Chemical Name:tert-butyl N-[2-[[5-methoxy-4-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-(prop-2-enoylamino)phenyl](methyl)amino]ethyl]-N-methylcarbamate
CAS No.:1421373-33-2
Molecular Formula:C₃₂H₃₉N₇O₄
Molecular Weight:585.706
Hs Code.:

Synonyms:tert-butyl N-[2-[[5-methoxy-4-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-(prop-2-enoylamino)phenyl](methyl)amino]ethyl]-N-methylcarbamate

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Chemical Property of tert-butyl N-[2-[[5-methoxy-4-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-(prop-2-enoylamino)phenyl](methyl)amino]ethyl]-N-methylcarbamate

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Technology Process of tert-butyl N-[2-[[5-methoxy-4-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-(prop-2-enoylamino)phenyl](methyl)amino]ethyl]-N-methylcarbamate

There total 11 articles about tert-butyl N-[2-[[5-methoxy-4-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-(prop-2-enoylamino)phenyl](methyl)amino]ethyl]-N-methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: tert-butyl (2-((2-(3-chloropropanamido)-5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)(methyl) amino)ethyl)(methyl)carbamate

: 1421373-33-2
tert-butyl N-[2-[[5-methoxy-4-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-(prop-2-enoylamino)phenyl](methyl)amino]ethyl]-N-methylcarbamate

Guidance literature:: With triethylamine; In acetonitrile; at 80 ℃; for 7h;
DOI:10.1016/j.bmcl.2020.127167

Reference yield:

: 1421372-94-2
N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indole-3-yl)-pyrimidine-2-amine

: 1421373-33-2
tert-butyl N-[2-[[5-methoxy-4-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-(prop-2-enoylamino)phenyl](methyl)amino]ethyl]-N-methylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 4 h / 100 °C / Microwave irradiation

2: iron; ammonium chloride / water; ethanol / 1.5 h / Reflux

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.58 h / Cooling

With iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; N,N-dimethyl acetamide; water;

Reference yield:

: 1421373-35-4
tert-butyl (2-((5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-nitrophenyl)(methyl)amino)ethyl)(methyl)carbamate

: 1421373-33-2
tert-butyl N-[2-[[5-methoxy-4-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-(prop-2-enoylamino)phenyl](methyl)amino]ethyl]-N-methylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: iron; ammonium chloride / water; ethanol / 1.5 h / Reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.58 h / Cooling

With iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; water;