tert-butyl (2-((5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-nitrophenyl)(methyl)amino)ethyl)(methyl)carbamate

Base Information

Chemical Name:tert-butyl (2-((5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-nitrophenyl)(methyl)amino)ethyl)(methyl)carbamate
CAS No.:1421373-35-4
Molecular Formula:C₂₉H₃₅N₇O₅
Molecular Weight:561.641
Hs Code.:

Synonyms:tert-butyl (2-((5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-nitrophenyl)(methyl)amino)ethyl)(methyl)carbamate

Suppliers and Price of tert-butyl (2-((5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-nitrophenyl)(methyl)amino)ethyl)(methyl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (2-((5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-nitrophenyl)(methyl)amino)ethyl)(methyl)carbamate

Chemical Property:

Boiling Point:751.4±70.0 °C(Predicted)
Density:1.25±0.1 g/cm3(Predicted)

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl (2-((5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-nitrophenyl)(methyl)amino)ethyl)(methyl)carbamate

There total 7 articles about tert-butyl (2-((5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-nitrophenyl)(methyl)amino)ethyl)(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1421372-94-2
N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indole-3-yl)-pyrimidine-2-amine

: 112257-19-9
tert-butyl N-methyl-N-<2-(methylamino)ethyl>carbamate

: 1421373-35-4
tert-butyl (2-((5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-nitrophenyl)(methyl)amino)ethyl)(methyl)carbamate

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 80 ℃; for 8h;
DOI:10.1016/j.bmcl.2020.127167

Reference yield:

: 1032452-86-0
2-chloro-4-(1'-methyl-1H-indol-3-yl)pyrimidine

: 1421373-35-4
tert-butyl (2-((5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-nitrophenyl)(methyl)amino)ethyl)(methyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / 2.5 h / 105 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 4 h / 100 °C / Microwave irradiation

With toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide;

Reference yield:

: 945016-63-7
3-(2-chloro-pyrimidin-4-yl)-1H-indole

: 1421373-35-4
tert-butyl (2-((5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-nitrophenyl)(methyl)amino)ethyl)(methyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

1.2: 3 h / 0 °C

2.1: toluene-4-sulfonic acid / 2.5 h / 105 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 4 h / 100 °C / Microwave irradiation

With sodium hydride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl acetamide; mineral oil;