N,N-di-n-propyl-(1-benzenesulfonyl-7-methoxy-4-indolyl)-(p-chlorophenylthio)-acetamide

Base Information

• Chemical Name: N,N-di-n-propyl-(1-benzenesulfonyl-7-methoxy-4-indolyl)-(p-chlorophenylthio)-acetamide
• CAS No.: 155602-54-3
• Molecular Formula: C₂₉H₃₁ClN₂O₄S₂
• Molecular Weight: 571.161
• Mol file: 155602-54-3.mol

Synonyms:N,N-di-n-propyl-(1-benzenesulfonyl-7-methoxy-4-indolyl)-(p-chlorophenylthio)-acetamide

Chemical Property of N,N-di-n-propyl-(1-benzenesulfonyl-7-methoxy-4-indolyl)-(p-chlorophenylthio)-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-di-n-propyl-(1-benzenesulfonyl-7-methoxy-4-indolyl)-(p-chlorophenylthio)-acetamide

There total 2 articles about N,N-di-n-propyl-(1-benzenesulfonyl-7-methoxy-4-indolyl)-(p-chlorophenylthio)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-methoxy-1H-indole (3189-22-8) → N,N-di-n-propyl-(1-benzenesulfonyl-7-methoxy-4-indolyl)-(p-chlorophenylthio)-acetamide (155602-54-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / NaOH, tetrabutylammonium hydrogen sulfate / CH₂Cl₂ / 4 h / 5 - 10 °C

2: 1.) TFAA, 2.) SnCl₄ / 1.) CH₂Cl₂, 0 deg C, 20 min, 2.) CH₂Cl₂, 0 deg C, 30 min

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; tin(IV) chloride; trifluoroacetic anhydride; In dichloromethane;

DOI:10.1080/00397919408011709

Reference yield:

benzenesulfonyl chloride (98-09-9) → N,N-di-n-propyl-(1-benzenesulfonyl-7-methoxy-4-indolyl)-(p-chlorophenylthio)-acetamide (155602-54-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / NaOH, tetrabutylammonium hydrogen sulfate / CH₂Cl₂ / 4 h / 5 - 10 °C

2: 1.) TFAA, 2.) SnCl₄ / 1.) CH₂Cl₂, 0 deg C, 20 min, 2.) CH₂Cl₂, 0 deg C, 30 min

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; tin(IV) chloride; trifluoroacetic anhydride; In dichloromethane;

DOI:10.1080/00397919408011709

Reference yield: 96.0%

N,N-di-n-propyl-(1-benzenesulfonyl-7-methoxy-4-indolyl)-(p-chlorophenylthio)-acetamide (155602-54-3) → N,N-di-n-propyl-(1-benzenesulfonyl-7-methoxy-4-indolyl)-acetamide (155602-55-4)

Guidance literature:

nickel; In ethyl acetate; for 2h; Ambient temperature;

DOI:10.1080/00397919408011709

upstream raw materials:

7-methoxy-1H-indole

benzenesulfonyl chloride

Downstream raw materials:

N,N-di-n-propyl-(1-benzenesulfonyl-7-methoxy-4-indolyl)-acetamide