(2S,2'S)-tetra-tert-butyl 2,2'-((5-([2,2'-bipyridine]-5-carboxamido)isophthaloyl)bis(azanediyl))disuccinate

Base Information

Chemical Name:(2S,2'S)-tetra-tert-butyl 2,2'-((5-([2,2'-bipyridine]-5-carboxamido)isophthaloyl)bis(azanediyl))disuccinate
CAS No.:1262887-75-1
Molecular Formula:C₄₃H₅₅N₅O₁₁
Molecular Weight:817.937
Hs Code.:

Synonyms:(2S,2'S)-tetra-tert-butyl 2,2'-((5-([2,2'-bipyridine]-5-carboxamido)isophthaloyl)bis(azanediyl))disuccinate

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Chemical Property of (2S,2'S)-tetra-tert-butyl 2,2'-((5-([2,2'-bipyridine]-5-carboxamido)isophthaloyl)bis(azanediyl))disuccinate

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Technology Process of (2S,2'S)-tetra-tert-butyl 2,2'-((5-([2,2'-bipyridine]-5-carboxamido)isophthaloyl)bis(azanediyl))disuccinate

There total 8 articles about (2S,2'S)-tetra-tert-butyl 2,2'-((5-([2,2'-bipyridine]-5-carboxamido)isophthaloyl)bis(azanediyl))disuccinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1262887-74-0
(2S,2'S)-tetra-tert-butyl 2,2'-((5-aminoisophthaloyl)bis(azanediyl))disuccinate

: 140447-00-3
2,2'-bipyridine-5-carbonyl chloride

: 1262887-75-1
(2S,2'S)-tetra-tert-butyl 2,2'-((5-([2,2'-bipyridine]-5-carboxamido)isophthaloyl)bis(azanediyl))disuccinate

Guidance literature:: With triethylamine; In chloroform; for 18h; Reflux; Inert atmosphere;
DOI:10.1039/c0cc04754f

Reference yield:

: 1122-62-9
2-acetylpyridine

: 1262887-75-1
(2S,2'S)-tetra-tert-butyl 2,2'-((5-([2,2'-bipyridine]-5-carboxamido)isophthaloyl)bis(azanediyl))disuccinate

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine; iodine / 4 h / 80 °C

2: ammonium acetate; formamide / 6 h / 80 °C

3: potassium permanganate; water / 5 h / 70 °C

4: thionyl chloride; N,N-dimethyl-formamide / Inert atmosphere; Reflux

5: triethylamine / chloroform / 18 h / Reflux; Inert atmosphere

With pyridine; potassium permanganate; thionyl chloride; ammonium acetate; water; iodine; formamide; triethylamine; N,N-dimethyl-formamide; In chloroform;
DOI:10.1039/c0cc04754f

Reference yield:

: 1262887-73-9
(2S,2'S)-tetra-tert-butyl 2,2'-((5-nitroisophthaloyl)bis(azanediyl))disuccinate

: 1262887-75-1
(2S,2'S)-tetra-tert-butyl 2,2'-((5-([2,2'-bipyridine]-5-carboxamido)isophthaloyl)bis(azanediyl))disuccinate

Guidance literature:: Multi-step reaction with 2 steps

1: 10% palladium on activated carbon; hydrogen / methanol

2: triethylamine / chloroform / 18 h / Reflux; Inert atmosphere

With 10% palladium on activated carbon; hydrogen; triethylamine; In methanol; chloroform;
DOI:10.1039/c0cc04754f