6-[(4-methoxyphenyl)methoxy]-1-[4-(phenylmethoxy)phenyl]hex-4-en-3-ol

Base Information

• Chemical Name: 6-[(4-methoxyphenyl)methoxy]-1-[4-(phenylmethoxy)phenyl]hex-4-en-3-ol
• CAS No.: 1428899-15-3
• Molecular Formula: C₂₇H₃₀O₄
• Molecular Weight: 418.533
• Mol file: 1428899-15-3.mol

Synonyms:6-[(4-methoxyphenyl)methoxy]-1-[4-(phenylmethoxy)phenyl]hex-4-en-3-ol

Chemical Property of 6-[(4-methoxyphenyl)methoxy]-1-[4-(phenylmethoxy)phenyl]hex-4-en-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-[(4-methoxyphenyl)methoxy]-1-[4-(phenylmethoxy)phenyl]hex-4-en-3-ol

There total 7 articles about 6-[(4-methoxyphenyl)methoxy]-1-[4-(phenylmethoxy)phenyl]hex-4-en-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

6-[(4-methoxyphenyl)methoxy]-1-[4-(phenylmethoxy)phenyl]hex-4-yn-3-ol (1428899-16-4) → 6-[(4-methoxyphenyl)methoxy]-1-[4-(phenylmethoxy)phenyl]hex-4-en-3-ol (1428899-15-3) + 6-[(4-methoxyphenyl)methoxy]-1-[4-(phenylmethoxy)phenyl]hex-4-en-3-ol

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 3h; Reflux;

DOI:10.1002/hlca.201200165

Reference yield:

3-(4-(benzyloxy)phenyl)propanal (68486-77-1) → 6-[(4-methoxyphenyl)methoxy]-1-[4-(phenylmethoxy)phenyl]hex-4-en-3-ol (1428899-15-3) + 6-[(4-methoxyphenyl)methoxy]-1-[4-(phenylmethoxy)phenyl]hex-4-en-3-ol

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 3 h / -78 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Reflux

With lithium aluminium tetrahydride; n-butyllithium; In tetrahydrofuran; hexane;

DOI:10.1002/hlca.201200165

Reference yield:

benzyl bromide (100-39-0) → 6-[(4-methoxyphenyl)methoxy]-1-[4-(phenylmethoxy)phenyl]hex-4-en-3-ol (1428899-15-3) + 6-[(4-methoxyphenyl)methoxy]-1-[4-(phenylmethoxy)phenyl]hex-4-en-3-ol

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran / 4 h / 0 - 20 °C

2.1: dichloromethane / 8 h / 20 °C

3.1: lithium borohydride / water; diethyl ether / 24 h / 0 - 20 °C

4.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 1.5 h / -78 °C

4.2: 0 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

5.2: 3 h / -78 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Reflux

With lithium aluminium tetrahydride; lithium borohydride; n-butyllithium; oxalyl dichloride; sodium hydride; dimethyl sulfoxide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; 2.1: |Wittig Olefination / 4.1: |Swern Oxidation / 4.2: |Swern Oxidation;

DOI:10.1002/hlca.201200165

upstream raw materials:

3-(4-(benzyloxy)phenyl)propanal

6-[(4-methoxyphenyl)methoxy]-1-[4-(phenylmethoxy)phenyl]hex-4-yn-3-ol

4-hydroxy-benzaldehyde

benzyl bromide

Downstream raw materials:

(1S)-1-{(2S,3S)-3-{[(4-methoxyphenyl)methoxy]methyl}oxiran-2-yl}-3-[4-(phenylmethoxy)phenyl]-propan-1-ol

(3R)-6-[(4-methoxyphenyl)methoxy]-1-[4-(phenylmethoxy)phenyl]hex-4-en-3-ol

(1R)-1-{(2R,3R)-3-{[(4-methoxyphenyl)methoxy]methyl}oxiran-2-yl}-3-[4-(phenylmethoxy)phenyl]propan-1-ol

(2S,4R)-1-[(4-methoxyphenyl)methoxy]-6-[4-(phenylmethoxy)phenyl]hexane-2,4-diol