3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 5'-O-<(2,2,2-tribromoethyl) morpholinophosphonate>

Base Information

• Chemical Name: 3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 5'-O-<(2,2,2-tribromoethyl) morpholinophosphonate>
• CAS No.: 72351-25-8
• Molecular Formula: C₃₀H₃₈Br₃N₆O₁₁P
• Molecular Weight: 929.351

Synonyms:3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 5'-O-<(2,2,2-tribromoethyl) morpholinophosphonate>

Chemical Property of 3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 5'-O-<(2,2,2-tribromoethyl) morpholinophosphonate>

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 5'-O-<(2,2,2-tribromoethyl) morpholinophosphonate>

There total 1 articles about 3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 5'-O-<(2,2,2-tribromoethyl) morpholinophosphonate> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2,2,2-tribromoethyl moprpholinophosphorochloridate (57575-15-2) + 3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine (71874-01-6) → 3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 5'-O-<(2,2,2-tribromoethyl) morpholinophosphonate> (72351-25-8)

Guidance literature:

With 1-methyl-1H-imidazole; In 1,4-dioxane; acetonitrile; for 6h;

DOI:10.1021/jo00324a010

Reference yield:

3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 5'-O-<(2,2,2-tribromoethyl) morpholinophosphonate> (72351-25-8) → C60H69Br3ClN11O21P2 (72351-29-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 0.25 h / 20 °C

2: 76 percent / 1-(2,4,6-triisopropylbenzenesulfonyl)-3-nitro-1,2,4-triazole (TPSNT) / pyridine / 3 h

With 1-(2,4,6-triisopropylbenzenesulfonyl)-3-nitro-1,2,4-triazole; In pyridine;

DOI:10.1021/jo00324a010

Reference yield:

3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine 5'-O-<(2,2,2-tribromoethyl) morpholinophosphonate> (72351-25-8) + 2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide) (72351-28-1) → Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-5-[6-(4-methoxy-benzoylamino)-purin-9-yl]-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester 2,2,2-tribromo-ethyl ester (72351-26-9)

Guidance literature:

In pyridine; at 20 ℃; for 0.25h;

DOI:10.1021/jo00324a010

upstream raw materials:

2,2,2-tribromoethyl moprpholinophosphorochloridate

3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine

Downstream raw materials:

Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-5-[6-(4-methoxy-benzoylamino)-purin-9-yl]-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester 2,2,2-tribromo-ethyl ester

C₆₀H₆₉Br₃ClN₁₁O₂₁P₂

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