Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-5-[6-(4-methoxy-benzoylamino)-purin-9-yl]-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester 2,2,2-tribromo-ethyl ester

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Chemical Name:Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-5-[6-(4-methoxy-benzoylamino)-purin-9-yl]-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester 2,2,2-tribromo-ethyl ester
CAS No.:72351-26-9
Molecular Formula:C₃₆H₄₂Br₃ClN₆O₁₄P₂
Molecular Weight:1119.87
Hs Code.:

Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-5-[6-(4-methoxy-benzoylamino)-purin-9-yl]-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester 2,2,2-tribromo-ethyl ester

Synonyms:Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-5-[6-(4-methoxy-benzoylamino)-purin-9-yl]-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester 2,2,2-tribromo-ethyl ester

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Chemical Property of Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-5-[6-(4-methoxy-benzoylamino)-purin-9-yl]-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester 2,2,2-tribromo-ethyl ester

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Technology Process of Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-5-[6-(4-methoxy-benzoylamino)-purin-9-yl]-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester 2,2,2-tribromo-ethyl ester

There total 4 articles about Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-5-[6-(4-methoxy-benzoylamino)-purin-9-yl]-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester 2,2,2-tribromo-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57575-15-2
2,2,2-tribromoethyl moprpholinophosphorochloridate

: 72351-26-9
Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-5-[6-(4-methoxy-benzoylamino)-purin-9-yl]-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester 2,2,2-tribromo-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / 1-methylimidazole / acetonitrile; dioxane / 6 h

2: pyridine / 0.25 h / 20 °C

With 1-methyl-1H-imidazole; In 1,4-dioxane; pyridine; acetonitrile;
DOI:10.1021/jo00324a010

Reference yield:

: 71874-01-6
3'-O-(4-methoxytetrahydropyran-4-yl)-6-N-p-anisoyladenosine

: 72351-26-9
Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-5-[6-(4-methoxy-benzoylamino)-purin-9-yl]-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester 2,2,2-tribromo-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / 1-methylimidazole / acetonitrile; dioxane / 6 h

2: pyridine / 0.25 h / 20 °C

With 1-methyl-1H-imidazole; In 1,4-dioxane; pyridine; acetonitrile;
DOI:10.1021/jo00324a010

Reference yield:

: 15074-54-1
2-chlorophenyl dichlorophosphate

: 72351-26-9
Morpholin-4-yl-phosphonic acid (2R,3R,4R,5R)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-5-[6-(4-methoxy-benzoylamino)-purin-9-yl]-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester 2,2,2-tribromo-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 0.5 h / 20 °C

2: pyridine / 0.25 h / 20 °C

With triethylamine; In tetrahydrofuran; pyridine;
DOI:10.1021/jo00324a010