dimethyl (R,Z)-2-(2-fluoro-5-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)benzamido)pentanedioate

Base Information

Chemical Name:dimethyl (R,Z)-2-(2-fluoro-5-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)benzamido)pentanedioate
CAS No.:1334590-78-1
Molecular Formula:C₁₈H₁₇FN₂O₆S₂
Molecular Weight:440.473
Hs Code.:

Synonyms:dimethyl (R,Z)-2-(2-fluoro-5-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)benzamido)pentanedioate

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Chemical Property of dimethyl (R,Z)-2-(2-fluoro-5-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)benzamido)pentanedioate

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Technology Process of dimethyl (R,Z)-2-(2-fluoro-5-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)benzamido)pentanedioate

There total 3 articles about dimethyl (R,Z)-2-(2-fluoro-5-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)benzamido)pentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 141-84-4
2-thioxo-4-thiazolidinone

: 1310744-58-1
(R)-1,5-dimethyl 2-(2-fluoro-5-formylbenzamido)pentanedioate

: 1334590-78-1
dimethyl (R,Z)-2-(2-fluoro-5-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)benzamido)pentanedioate

Guidance literature:: With piperidine; acetic acid; In ethanol; at 150 ℃; for 0.333333h; Microwave irradiation;
DOI:10.1016/j.ejmech.2011.05.070

Reference yield:

: 550363-85-4
2-fluoro-5-formyl-benzoic acid

: 1334590-78-1
dimethyl (R,Z)-2-(2-fluoro-5-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)benzamido)pentanedioate

Guidance literature:: Multi-step reaction with 2 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 3.25 h / 20 °C

2: piperidine; acetic acid / ethanol / 0.33 h / 150 °C / Microwave irradiation

With piperidine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; triethylamine; In ethanol; dichloromethane; 2: Knoevenagel condensation;
DOI:10.1016/j.ejmech.2011.05.070

Reference yield:

: 13515-99-6,23150-65-4,27025-25-8
D-glutamic acid dimethyl ester hydrochloride

: 1334590-78-1
dimethyl (R,Z)-2-(2-fluoro-5-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)benzamido)pentanedioate

Guidance literature:: Multi-step reaction with 2 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 3.25 h / 20 °C

2: piperidine; acetic acid / ethanol / 0.33 h / 150 °C / Microwave irradiation

With piperidine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; triethylamine; In ethanol; dichloromethane; 2: Knoevenagel condensation;
DOI:10.1016/j.ejmech.2011.05.070