Technology Process of 5-bromo-2-(4-fluorophenyl)-N-methyl-6-(methylsulfonamido)-2H-indazole-3-carboxamide
There total 9 articles about 5-bromo-2-(4-fluorophenyl)-N-methyl-6-(methylsulfonamido)-2H-indazole-3-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
pyridine; dichloromethane;
at 0 - 25 ℃;
for 8.5h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sulfuric acid; nitric acid / 5.92 h / 50 °C / Cooling with ice
2.1: acetic acid / 0.08 h / 60 °C
2.2: 0.08 h / 60 °C
3.1: phosphorus trichloride / chloroform / 1 h / 60 °C
4.1: ammonium chloride; iron / methanol; tetrahydrofuran; water / 1.5 h / 80 °C
5.1: sodium hydroxide / water / 48 h / 100 °C
6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 20 °C
6.2: 2 h
7.1: pyridine / dichloromethane / 8.5 h / 0 - 25 °C / Inert atmosphere
With
pyridine; sulfuric acid; nitric acid; iron; ammonium chloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; phosphorus trichloride;
In
tetrahydrofuran; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sulfuric acid; nitric acid / 0.42 h / 0 °C
2.1: sulfuric acid; nitric acid / 5.92 h / 50 °C / Cooling with ice
3.1: acetic acid / 0.08 h / 60 °C
3.2: 0.08 h / 60 °C
4.1: phosphorus trichloride / chloroform / 1 h / 60 °C
5.1: ammonium chloride; iron / methanol; tetrahydrofuran; water / 1.5 h / 80 °C
6.1: sodium hydroxide / water / 48 h / 100 °C
7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 20 °C
7.2: 2 h
8.1: pyridine / dichloromethane / 8.5 h / 0 - 25 °C / Inert atmosphere
With
pyridine; sulfuric acid; nitric acid; iron; ammonium chloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; phosphorus trichloride;
In
tetrahydrofuran; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;
