2-{3-[((S)-1-Dimethylaminomethyl-3,3-dimethyl-butylamino)-methyl]-benzyl}1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid ethyl ester

Base Information

Chemical Name:2-{3-[((S)-1-Dimethylaminomethyl-3,3-dimethyl-butylamino)-methyl]-benzyl}1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid ethyl ester
CAS No.:1308662-41-0
Molecular Formula:C₂₃H₃₉N₃O₄S
Molecular Weight:453.646
Hs Code.:

Synonyms:2-{3-[((S)-1-Dimethylaminomethyl-3,3-dimethyl-butylamino)-methyl]-benzyl}1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid ethyl ester

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Chemical Property of 2-{3-[((S)-1-Dimethylaminomethyl-3,3-dimethyl-butylamino)-methyl]-benzyl}1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 2-{3-[((S)-1-Dimethylaminomethyl-3,3-dimethyl-butylamino)-methyl]-benzyl}1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid ethyl ester

There total 8 articles about 2-{3-[((S)-1-Dimethylaminomethyl-3,3-dimethyl-butylamino)-methyl]-benzyl}1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82072-23-9
3-(bromomethyl)benzaldehyde

: 1308662-41-0
2-{3-[((S)-1-Dimethylaminomethyl-3,3-dimethyl-butylamino)-methyl]-benzyl}1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / dichloromethane; N,N-dimethyl-formamide / 20 h / 20 °C

2.1: triethylamine; acetic acid / methanol / 0.42 h / 0 °C / Cooling with ice

2.2: 2 h / 0 - 20 °C

2.3: 0 - 20 °C

With caesium carbonate; acetic acid; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1308662-07-8
2-(3-Formyl-benzyl)-1,1-dioxo-1λ6 isothiazolidine-3-carboxylic acid ethyl ester

: (S)-4,4,N₁,N₁-tetramethyl-pentane-1,2-diamine hydrochloride

: 1308662-41-0
2-{3-[((S)-1-Dimethylaminomethyl-3,3-dimethyl-butylamino)-methyl]-benzyl}1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid ethyl ester

Guidance literature:: (S)-4,4,N₁,N₁-tetramethyl-pentane-1,2-diamine hydrochloride; With acetic acid; triethylamine; In methanol; at 0 ℃; for 0.416667h; Cooling with ice;

2-(3-Formyl-benzyl)-1,1-dioxo-1λ6 isothiazolidine-3-carboxylic acid ethyl ester; In methanol; at 0 - 20 ℃; for 2h;

With sodium cyanoborohydride; acetic acid; In methanol; at 0 - 20 ℃;

Reference yield:

: 1253789-57-9
1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid ethyl ester

: 1308662-41-0
2-{3-[((S)-1-Dimethylaminomethyl-3,3-dimethyl-butylamino)-methyl]-benzyl}1,1-dioxo-1λ6-isothiazolidine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / dichloromethane; N,N-dimethyl-formamide / 20 h / 20 °C

2.1: triethylamine; acetic acid / methanol / 0.42 h / 0 °C / Cooling with ice

2.2: 2 h / 0 - 20 °C

2.3: 0 - 20 °C

With caesium carbonate; acetic acid; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;