2-acetoxy-2-phenylacetic acid

Base Information

• Chemical Name: 2-acetoxy-2-phenylacetic acid
• CAS No.: 29071-09-8
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 194.187
• Mol file: 29071-09-8.mol

Synonyms:2-acetoxy-2-phenylacetic acid

Chemical Property of 2-acetoxy-2-phenylacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-acetoxy-2-phenylacetic acid

There total 23 articles about 2-acetoxy-2-phenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

acetic anhydride (108-24-7) + MANDELIC ACID (611-71-2,611-72-3,17199-29-0,90-64-2) → 2-acetoxy-2-phenylacetic acid (29071-09-8)

Guidance literature:

With pyridine; for 16h;

DOI:10.1016/j.bmcl.2008.02.009

Reference yield: 96.0%

MANDELIC ACID (611-71-2,611-72-3,17199-29-0,90-64-2) + acetyl chloride (75-36-5) → 2-acetoxy-2-phenylacetic acid (29071-09-8)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 24h;

DOI:10.1021/acs.orglett.1c02080

Reference yield: 93.0%

Acetoxy-phenyl-acetic acid prop-2-ynyl ester (182342-84-3) → 2-acetoxy-2-phenylacetic acid (29071-09-8)

Guidance literature:

With benzyltriethylammonium tetrathiomolybdate; In acetonitrile; at 25 ℃; for 23h;

DOI:10.1039/cc9960001957

upstream raw materials:

Ketene

MANDELIC ACID

Acetyl bromide

acetic anhydride

Downstream raw materials:

naphthalene-1,5-diyl bis<(acetoxy)(phenyl)acetate>

2-methyl-5-phenylfurandicarboxylic acid dimethyl ester

rac-3,3,3-trifluoro-2-hydroxy-1-phenylpropan-1-one

(S)-acetylmandelic acid

Refernces

• 1、 Muthuraja, Perumal,Usman, Rahamdil,Sajeev, Revathy,Gopinath, Purushothaman. "Controlled meta-Selective C-H Mono- And Di-Olefination of Mandelic Acid Derivatives". supporting information. p. 6014 - 6018. Retrieved 2021/08/03.
• 2、 Moore, Desiree L.,Denton, Allison E.,Kohinke, Rose M.,Craig, Brandon R.,Brenzovich, William E.. "Silica sulfuric acid as a highly efficient catalyst for the synthesis of diarylacetic acids". . p. 604 - 612. Retrieved 2016/07/06.