2-(4-Methoxyphenyl)-N-(4-methylbenzyl)-N-[1-(2-methylthiazol-4-ylmethyl) piperidin-4-yl] acetamide

Base Information

Chemical Name:2-(4-Methoxyphenyl)-N-(4-methylbenzyl)-N-[1-(2-methylthiazol-4-ylmethyl) piperidin-4-yl] acetamide
CAS No.:359879-02-0
Molecular Formula:C₂₇H₃₃N₃O₂S
Molecular Weight:463.644
Hs Code.:

Synonyms:2-(4-Methoxyphenyl)-N-(4-methylbenzyl)-N-[1-(2-methylthiazol-4-ylmethyl) piperidin-4-yl] acetamide

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Chemical Property of 2-(4-Methoxyphenyl)-N-(4-methylbenzyl)-N-[1-(2-methylthiazol-4-ylmethyl) piperidin-4-yl] acetamide

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Technology Process of 2-(4-Methoxyphenyl)-N-(4-methylbenzyl)-N-[1-(2-methylthiazol-4-ylmethyl) piperidin-4-yl] acetamide

There total 5 articles about 2-(4-Methoxyphenyl)-N-(4-methylbenzyl)-N-[1-(2-methylthiazol-4-ylmethyl) piperidin-4-yl] acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 359878-14-1
N-((4-methylphenyl)methyl)-N-(piperidin-4-yl)-4-methoxyphenylacetamide

: 77470-53-2
4-chloromethyl-2-methylthiazole hydrochloride

: 359879-02-0
2-(4-Methoxyphenyl)-N-(4-methylbenzyl)-N-[1-(2-methylthiazol-4-ylmethyl) piperidin-4-yl] acetamide

Guidance literature:: With hydrogenchloride; potassium iodide; potassium carbonate; In dichloromethane; acetonitrile;

Reference yield:

: 104-84-7
para-methylbenzylamine

: 359879-02-0
2-(4-Methoxyphenyl)-N-(4-methylbenzyl)-N-[1-(2-methylthiazol-4-ylmethyl) piperidin-4-yl] acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium cyanoborohydride; acetic acid / methanol / 20 h / 20 °C

1.2: 1 h

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 50 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane; diethyl ether / 2 h / 20 °C

4.1: potassium carbonate; potassium iodide / acetonitrile / 20 h / 82 °C

With hydrogenchloride; sodium cyanoborohydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; potassium iodide; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; acetonitrile;

Reference yield:

: N-((4-methylphenyl)methyl)-N-(1-(tert-butyloxycarbonyl)piperidin-4-yl)-4-methoxyphenylacetamide

: 359879-02-0
2-(4-Methoxyphenyl)-N-(4-methylbenzyl)-N-[1-(2-methylthiazol-4-ylmethyl) piperidin-4-yl] acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; diethyl ether / 2 h / 20 °C

2: potassium carbonate; potassium iodide / acetonitrile / 20 h / 82 °C

With hydrogenchloride; potassium carbonate; potassium iodide; In 1,4-dioxane; diethyl ether; acetonitrile;