4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-5-(4-methoxy-2-methyl-5-(1-(pyrimidin-2-yl)cyclopropyl)carbamoyl)phenyl-N-methylbenzofuran-3-carboxamide

Base Information

Chemical Name:4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-5-(4-methoxy-2-methyl-5-(1-(pyrimidin-2-yl)cyclopropyl)carbamoyl)phenyl-N-methylbenzofuran-3-carboxamide
CAS No.:1353895-73-4
Molecular Formula:C₃₈H₃₀F₂N₄O₅
Molecular Weight:660.677
Hs Code.:

4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-5-(4-methoxy-2-methyl-5-(1-(pyrimidin-2-yl)cyclopropyl)carbamoyl)phenyl-N-methylbenzofuran-3-carboxamide

Synonyms:4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-5-(4-methoxy-2-methyl-5-(1-(pyrimidin-2-yl)cyclopropyl)carbamoyl)phenyl-N-methylbenzofuran-3-carboxamide

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Chemical Property of 4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-5-(4-methoxy-2-methyl-5-(1-(pyrimidin-2-yl)cyclopropyl)carbamoyl)phenyl-N-methylbenzofuran-3-carboxamide

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Technology Process of 4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-5-(4-methoxy-2-methyl-5-(1-(pyrimidin-2-yl)cyclopropyl)carbamoyl)phenyl-N-methylbenzofuran-3-carboxamide

There total 11 articles about 4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-5-(4-methoxy-2-methyl-5-(1-(pyrimidin-2-yl)cyclopropyl)carbamoyl)phenyl-N-methylbenzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.1%

: 1215107-61-1
1-(pyrimidin-2-yl)cyclopropan-1-amine hydrochloride

: 1353895-89-2
5-(4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-3-(methylcarbamoyl)benzofuran-5-yl)-2-methoxy-4-methylbenzoic acid

: 1353895-73-4
4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-5-(4-methoxy-2-methyl-5-(1-(pyrimidin-2-yl)cyclopropyl)carbamoyl)phenyl-N-methylbenzofuran-3-carboxamide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 1353895-75-6
4-fluoro-2-(4-bromophenyl)-5-hydroxybenzofuran-3-carboxylic acid

: 1353895-73-4
4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-5-(4-methoxy-2-methyl-5-(1-(pyrimidin-2-yl)cyclopropyl)carbamoyl)phenyl-N-methylbenzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 20 °C / Inert atmosphere

2: caesium carbonate / 1-methyl-pyrrolidin-2-one / 16 h / 50 °C / Sealed tube

3: potassium phosphate / palladium diacetate; XPhos / toluene / 16 h / 50 °C / Sealed tube; Inert atmosphere

4: boron trichloride / dichloromethane / 3 h / 20 °C

5: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

6: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 100 °C / Inert atmosphere

7: sodium hydroxide; methanol / tetrahydrofuran / 3 h / 20 - 60 °C

8: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0 - 20 °C

With methanol; potassium phosphate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; boron trichloride; sodium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; XPhos; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 26510-95-2
ethyl 4-Bromobenzoylacetate

: 1353895-73-4
4-fluoro-2-(4-(4-fluorophenoxy)phenyl)-5-(4-methoxy-2-methyl-5-(1-(pyrimidin-2-yl)cyclopropyl)carbamoyl)phenyl-N-methylbenzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 11 steps

1: zinc(II) chloride / ethanol / 120 °C

2: Selectfluor / acetonitrile / 24 h / 20 °C

3: sodium hydroxide; water / tetrahydrofuran; methanol / 4 h / 60 °C

4: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 20 °C / Inert atmosphere

5: caesium carbonate / 1-methyl-pyrrolidin-2-one / 16 h / 50 °C / Sealed tube

6: potassium phosphate / palladium diacetate; XPhos / toluene / 16 h / 50 °C / Sealed tube; Inert atmosphere

7: boron trichloride / dichloromethane / 3 h / 20 °C

8: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

9: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 100 °C / Inert atmosphere

10: sodium hydroxide; methanol / tetrahydrofuran / 3 h / 20 - 60 °C

11: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0 - 20 °C

With methanol; potassium phosphate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; boron trichloride; sodium carbonate; benzotriazol-1-ol; caesium carbonate; Selectfluor; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; zinc(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; XPhos; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;