4-chloro-N-(2-((4-chlorophenyl)thio)phenyl)benzenesulfonamide

Base Information

• Chemical Name: 4-chloro-N-(2-((4-chlorophenyl)thio)phenyl)benzenesulfonamide
• CAS No.: 245649-77-8
• Molecular Formula: C₁₈H₁₃Cl₂NO₂S₂
• Molecular Weight: 410.345
• Mol file: 245649-77-8.mol

Synonyms:4-chloro-N-(2-((4-chlorophenyl)thio)phenyl)benzenesulfonamide

Chemical Property of 4-chloro-N-(2-((4-chlorophenyl)thio)phenyl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-chloro-N-(2-((4-chlorophenyl)thio)phenyl)benzenesulfonamide

There total 4 articles about 4-chloro-N-(2-((4-chlorophenyl)thio)phenyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-chlorophenyl 2-nitrophenyl sulfide (6764-10-9) + sodium p-chlorobenzenesulphinate (14752-66-0) → 4-chloro-N-(2-((4-chlorophenyl)thio)phenyl)benzenesulfonamide (245649-77-8)

Guidance literature:

With sodium hydrogensulfite; In water; dimethyl sulfoxide; at 60 ℃; for 24h; chemoselective reaction;

DOI:10.1016/j.tetlet.2018.10.032

Reference yield:

4-chlorobenzenesulfonyl chloride (98-60-2) → 4-chloro-N-(2-((4-chlorophenyl)thio)phenyl)benzenesulfonamide (245649-77-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium sulfite; sodium hydrogencarbonate / water / 3 h / 80 - 90 °C

2: sodium hydrogensulfite / water; dimethyl sulfoxide / 24 h / 60 °C

With sodium hydrogencarbonate; sodium hydrogensulfite; sodium sulfite; In water; dimethyl sulfoxide;

DOI:10.1016/j.tetlet.2018.10.032

Reference yield:

p-Chlorothiophenol (106-54-7) + ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → 4-chloro-N-(2-((4-chlorophenyl)thio)phenyl)benzenesulfonamide (245649-77-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / water / 10 h / 50 °C

2: sodium hydrogensulfite / water; dimethyl sulfoxide / 24 h / 60 °C

With potassium carbonate; sodium hydrogensulfite; In water; dimethyl sulfoxide;

DOI:10.1016/j.tetlet.2018.10.032

upstream raw materials:

p-Chlorothiophenol

ortho-nitrofluorobenzene

4-chlorophenyl 2-nitrophenyl sulfide

sodium p-chlorobenzenesulphinate

Downstream raw materials:

2-(4-Chlorophenylthio)-N-(4-chlorobenzenesulfonyl)-N-(2-dimethylaminoethyl)aniline.HCl