3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1-(3,4-dihydroxy-5-(trityloxymethyl)-tetrahydrofuran-2-yl)-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1-(3,4-dihydroxy-5-(trityloxymethyl)-tetrahydrofuran-2-yl)-1H-pyrimidine-2,4-dione
CAS No.:1380572-70-2
Molecular Formula:C₄₃H₃₅Cl₅N₂O₈
Molecular Weight:885.024
Hs Code.:

3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1-(3,4-dihydroxy-5-(trityloxymethyl)-tetrahydrofuran-2-yl)-1H-pyrimidine-2,4-dione

Synonyms:3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1-(3,4-dihydroxy-5-(trityloxymethyl)-tetrahydrofuran-2-yl)-1H-pyrimidine-2,4-dione

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Chemical Property of 3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1-(3,4-dihydroxy-5-(trityloxymethyl)-tetrahydrofuran-2-yl)-1H-pyrimidine-2,4-dione

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Technology Process of 3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1-(3,4-dihydroxy-5-(trityloxymethyl)-tetrahydrofuran-2-yl)-1H-pyrimidine-2,4-dione

There total 6 articles about 3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1-(3,4-dihydroxy-5-(trityloxymethyl)-tetrahydrofuran-2-yl)-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1380572-68-8
3-[(2,6-dichloro-4-methoxy-phenyl)-(2,4,6-trichloro-phenyl)-methoxymethyl]-1-(3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione

: 76-83-5
trityl chloride

: 1380572-70-2
3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1-(3,4-dihydroxy-5-(trityloxymethyl)-tetrahydrofuran-2-yl)-1H-pyrimidine-2,4-dione

Guidance literature:: With pyridine; dmap; at 60 ℃; for 4h;
DOI:10.1016/j.tet.2012.03.121

Reference yield:

: 1380572-66-6
(((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl) methyl sulfide

: 1380572-70-2
3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1-(3,4-dihydroxy-5-(trityloxymethyl)-tetrahydrofuran-2-yl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuryl dichloride / dichloromethane / 1 h / 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0 °C

3: pyridine; dmap / 4 h / 60 °C

With pyridine; dmap; sulfuryl dichloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.03.121

Reference yield:

: 1380572-64-4
(2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methanone

: 1380572-70-2
3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1-(3,4-dihydroxy-5-(trityloxymethyl)-tetrahydrofuran-2-yl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C

2.2: 3 h / 0 °C

3.1: sulfuryl dichloride / dichloromethane / 1 h / 20 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0 °C

5.1: pyridine; dmap / 4 h / 60 °C

With pyridine; dmap; lithium borohydride; sulfuryl dichloride; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tet.2012.03.121