6-(tert-butyldiphenylsilyloxy)-2-hydroxy-3-iodobenzoic acid methyl ester

Base Information

Chemical Name:6-(tert-butyldiphenylsilyloxy)-2-hydroxy-3-iodobenzoic acid methyl ester
CAS No.:641616-52-6
Molecular Formula:C₂₄H₂₅IO₄Si
Molecular Weight:532.45
Hs Code.:

Synonyms:6-(tert-butyldiphenylsilyloxy)-2-hydroxy-3-iodobenzoic acid methyl ester

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Chemical Property of 6-(tert-butyldiphenylsilyloxy)-2-hydroxy-3-iodobenzoic acid methyl ester

Chemical Property:

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Technology Process of 6-(tert-butyldiphenylsilyloxy)-2-hydroxy-3-iodobenzoic acid methyl ester

There total 1 articles about 6-(tert-butyldiphenylsilyloxy)-2-hydroxy-3-iodobenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2150-45-0
methyl 2,6-dihydroxybenzoate

: 58479-61-1
tert-butylchlorodiphenylsilane

: 2,6-dihydroxy-3,5-diiodobenzoic acid methyl ester

: 641616-52-6
6-(tert-butyldiphenylsilyloxy)-2-hydroxy-3-iodobenzoic acid methyl ester

Guidance literature:: methyl 2,6-dihydroxybenzoate; With Iodine monochloride; In tetrachloromethane; at 20 ℃; for 48h;

tert-butylchlorodiphenylsilane; With 1H-imidazole; In dichloromethane; at 20 ℃; for 5h;
DOI:10.1016/j.bmcl.2003.08.063

Reference yield: 72.0%

: 641616-52-6
6-(tert-butyldiphenylsilyloxy)-2-hydroxy-3-iodobenzoic acid methyl ester

: 74-88-4
methyl iodide

: 641616-53-7
6-(tert-butyldiphenylsilyloxy)-3-iodo-2-methoxybenzoic acid methyl ester

Guidance literature:: With potassium hydrogencarbonate; In acetone; for 24h; Heating;
DOI:10.1016/j.bmcl.2003.08.063

Reference yield:

: 641616-52-6
6-(tert-butyldiphenylsilyloxy)-2-hydroxy-3-iodobenzoic acid methyl ester

: 132448-74-9
5-Iodo-BZM

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / KHCO₃ / acetone / 24 h / Heating

2: 95 percent / Bu₄NF / tetrahydrofuran / 2 h / 20 °C

3: 74 percent / KOH / dioxane

4: 42 percent / dicyclohexylcarbodiimide; 1-hydroxy-benzotriazole hydrate / CH₂Cl₂ / 18 h / 20 °C

With potassium hydroxide; tetrabutyl ammonium fluoride; potassium hydrogencarbonate; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetone;
DOI:10.1016/j.bmcl.2003.08.063