2-{4-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-7-oxo-[1,4]diazepan-1-yl}-succinic acid 1-methyl ester

Base Information

Chemical Name:2-{4-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-7-oxo-[1,4]diazepan-1-yl}-succinic acid 1-methyl ester
CAS No.:1290047-57-2
Molecular Formula:C₁₉H₂₀Cl₂N₂O₆
Molecular Weight:443.284
Hs Code.:

Synonyms:2-{4-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-7-oxo-[1,4]diazepan-1-yl}-succinic acid 1-methyl ester

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Chemical Property of 2-{4-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-7-oxo-[1,4]diazepan-1-yl}-succinic acid 1-methyl ester

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Technology Process of 2-{4-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-7-oxo-[1,4]diazepan-1-yl}-succinic acid 1-methyl ester

There total 4 articles about 2-{4-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-7-oxo-[1,4]diazepan-1-yl}-succinic acid 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7312-27-8
3,4-Dichlorocinnamic acid

: 1290047-57-2
2-{4-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-7-oxo-[1,4]diazepan-1-yl}-succinic acid 1-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C

1.2: 0 - 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C

2.2: -78 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

3.2: 5 h / -78 °C

4.1: hydrogenchloride; water / 1,4-dioxane / 6 - 20 °C

With hydrogenchloride; oxalyl dichloride; water; lithium hexamethyldisilazane; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

Reference yield:

: 34376-54-0
[1,4]diazepan-5-one

: 1290047-57-2
2-{4-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-7-oxo-[1,4]diazepan-1-yl}-succinic acid 1-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C

1.2: 0 - 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C

2.2: -78 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

3.2: 5 h / -78 °C

4.1: hydrogenchloride; water / 1,4-dioxane / 6 - 20 °C

With hydrogenchloride; oxalyl dichloride; water; lithium hexamethyldisilazane; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

Reference yield:

: 1290047-58-3
{4-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-7-oxo-[1,4]diazepan-1-yl}-acetic acid methyl ester

: 1290047-57-2
2-{4-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-7-oxo-[1,4]diazepan-1-yl}-succinic acid 1-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

1.2: 5 h / -78 °C

2.1: hydrogenchloride; water / 1,4-dioxane / 6 - 20 °C

With hydrogenchloride; water; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane;