1,4-cyclohexadiene-1-pentanoic acid 2,5-bis(1-aziridinyl)-4-methyl-3,6-dioxo methyl ester

Base Information

Chemical Name:1,4-cyclohexadiene-1-pentanoic acid 2,5-bis(1-aziridinyl)-4-methyl-3,6-dioxo methyl ester
CAS No.:259674-47-0
Molecular Formula:C₁₇H₂₂N₂O₄
Molecular Weight:318.373
Hs Code.:

Synonyms:1,4-cyclohexadiene-1-pentanoic acid 2,5-bis(1-aziridinyl)-4-methyl-3,6-dioxo methyl ester

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Chemical Property of 1,4-cyclohexadiene-1-pentanoic acid 2,5-bis(1-aziridinyl)-4-methyl-3,6-dioxo methyl ester

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Technology Process of 1,4-cyclohexadiene-1-pentanoic acid 2,5-bis(1-aziridinyl)-4-methyl-3,6-dioxo methyl ester

There total 5 articles about 1,4-cyclohexadiene-1-pentanoic acid 2,5-bis(1-aziridinyl)-4-methyl-3,6-dioxo methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 151-56-4,9002-98-6
ethyleneimine

: 208459-96-5
1,4-cyclohexadiene-1-pentanoic acid 4-methyl-3,6-dioxo methyl ester

: 259674-47-0
1,4-cyclohexadiene-1-pentanoic acid 2,5-bis(1-aziridinyl)-4-methyl-3,6-dioxo methyl ester

Guidance literature:: With copper diacetate; In methanol;
DOI:10.1021/ja973819u

Reference yield:

: 21565-82-2
methyl pent-4-ynoate

: 259674-47-0
1,4-cyclohexadiene-1-pentanoic acid 2,5-bis(1-aziridinyl)-4-methyl-3,6-dioxo methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 51 percent / CuI, Pd(PPh₃)4, EtN(iPr)2 / dimethylformamide

2: 96 percent / H₂, HCO₂H, triethylammonium formate / 10 percent Pd/C / ethanol / 19 h / Ambient temperature

3: 71 percent / aq. (NH₄)2Ce(NO₃)6 / acetonitrile / 0.75 h

4: 90 percent / Cu(OAc)2 / methanol

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; formic acid; copper diacetate; ammonium cerium(IV) nitrate; hydrogen; triethylammonium formate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja973819u

Reference yield:

: 208459-94-3
4-pentynoic acid 5-(2,5-dimethoxy-4-methylphenyl) methyl ester

: 259674-47-0
1,4-cyclohexadiene-1-pentanoic acid 2,5-bis(1-aziridinyl)-4-methyl-3,6-dioxo methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / H₂, HCO₂H, triethylammonium formate / 10 percent Pd/C / ethanol / 19 h / Ambient temperature

2: 71 percent / aq. (NH₄)2Ce(NO₃)6 / acetonitrile / 0.75 h

3: 90 percent / Cu(OAc)2 / methanol

With formic acid; copper diacetate; ammonium cerium(IV) nitrate; hydrogen; triethylammonium formate; palladium on activated charcoal; In methanol; ethanol; acetonitrile;
DOI:10.1021/ja973819u