4-methyl-4-(2,3,5-trifluorobenzyl)-6-[3-(2,2,2-trifluoroethoxy)phenyl]-1,4-dihydroisoquinolin-3(2H)-one

Base Information

Chemical Name:4-methyl-4-(2,3,5-trifluorobenzyl)-6-[3-(2,2,2-trifluoroethoxy)phenyl]-1,4-dihydroisoquinolin-3(2H)-one
CAS No.:1207713-71-0
Molecular Formula:C₂₅H₁₉F₆NO₂
Molecular Weight:479.422
Hs Code.:

Synonyms:4-methyl-4-(2,3,5-trifluorobenzyl)-6-[3-(2,2,2-trifluoroethoxy)phenyl]-1,4-dihydroisoquinolin-3(2H)-one

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Chemical Property of 4-methyl-4-(2,3,5-trifluorobenzyl)-6-[3-(2,2,2-trifluoroethoxy)phenyl]-1,4-dihydroisoquinolin-3(2H)-one

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Technology Process of 4-methyl-4-(2,3,5-trifluorobenzyl)-6-[3-(2,2,2-trifluoroethoxy)phenyl]-1,4-dihydroisoquinolin-3(2H)-one

There total 1 articles about 4-methyl-4-(2,3,5-trifluorobenzyl)-6-[3-(2,2,2-trifluoroethoxy)phenyl]-1,4-dihydroisoquinolin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 850593-08-7
(3-(2,2,2-trifluoroethoxy)phenyl)boronic acid

: 1207713-95-8
6-bromo-4-methyl-4-(2,3,5-trifluorobenzyl)-1,4-dihydroisoquinolin-3(2H)-one

: 1207713-71-0
4-methyl-4-(2,3,5-trifluorobenzyl)-6-[3-(2,2,2-trifluoroethoxy)phenyl]-1,4-dihydroisoquinolin-3(2H)-one

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 80 ℃; for 15h;

Reference yield:

: 1207713-71-0
4-methyl-4-(2,3,5-trifluorobenzyl)-6-[3-(2,2,2-trifluoroethoxy)phenyl]-1,4-dihydroisoquinolin-3(2H)-one

: 71759-87-0
4-iodo-1-methyl-1H-imidazole

: 1207713-76-5
4-methyl-4-(2,3,5-trifluorobenzyl)-6-[3-(2,2,2-trifluoroethoxy)phenyl]isoquinoline-1,3(2H,4H)-dione

: 1207713-62-9
4-methyl-2-(1-methyl-1H-imidazol-4-yl)-4-(2,3,5-trifluorobenzyl)-6-[3-(2,2,2-trifluoroethoxy)phenyl]-1,4-dihydroisoquinolin-3(2H)-one

: 1207713-67-4
4-methyl-2-(1-methyl-1H-imidazol-4-yl)-4-(2,3,5-trifluorobenzyl)-6-[3-(2,2,2-trifluoroethoxy)phenyl]isoquinoline-1,3(2H,4H)-dione

Guidance literature:: With potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine; In toluene; at 100 ℃; for 16h;

Reference yield:

: 1207713-71-0
4-methyl-4-(2,3,5-trifluorobenzyl)-6-[3-(2,2,2-trifluoroethoxy)phenyl]-1,4-dihydroisoquinolin-3(2H)-one

: 74-88-4
methyl iodide

: 1207713-64-1
2,4-dimethyl-4-(2,3,5-trifluorobenzyl)-6-[3-(2,2,2-trifluoroethoxy)phenyl]-1,4-dihydroisoquinolin-3(2H)-one

Guidance literature:: 4-methyl-4-(2,3,5-trifluorobenzyl)-6-[3-(2,2,2-trifluoroethoxy)phenyl]-1,4-dihydroisoquinolin-3(2H)-one; With sodium hydride; In N,N-dimethyl-formamide; for 0.333333h;

methyl iodide; In N,N-dimethyl-formamide; for 2.5h;