6-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methyl-phenylamino]-2-(2,4-difluoro-phenyl)-nicotinic acid methyl ester

Base Information

Chemical Name:6-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methyl-phenylamino]-2-(2,4-difluoro-phenyl)-nicotinic acid methyl ester
CAS No.:1380281-69-5
Molecular Formula:C₂₈H₂₆F₂N₄O₂
Molecular Weight:488.537
Hs Code.:

Synonyms:6-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methyl-phenylamino]-2-(2,4-difluoro-phenyl)-nicotinic acid methyl ester

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Chemical Property of 6-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methyl-phenylamino]-2-(2,4-difluoro-phenyl)-nicotinic acid methyl ester

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Technology Process of 6-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methyl-phenylamino]-2-(2,4-difluoro-phenyl)-nicotinic acid methyl ester

There total 10 articles about 6-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methyl-phenylamino]-2-(2,4-difluoro-phenyl)-nicotinic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1380281-68-4
6-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenylamino]-2-chloronicotinic acid methyl ester

: 144025-03-6
2,4-difluorophenylboronic acid

: 1380281-69-5
6-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methyl-phenylamino]-2-(2,4-difluoro-phenyl)-nicotinic acid methyl ester

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; at 75 ℃; for 18h;

Reference yield:

: 65515-28-8
methyl 2,6-dichloronicotinate

: 1380281-69-5
6-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methyl-phenylamino]-2-(2,4-difluoro-phenyl)-nicotinic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 18 h / 85 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water / 18 h / 75 °C

With sodium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In ethanol; water; toluene; 2: Suzuki Coupling;

Reference yield:

: 38496-18-3
2,6-dichloropyridine-3-carboxylic acid

: 1380281-69-5
6-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methyl-phenylamino]-2-(2,4-difluoro-phenyl)-nicotinic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / 80 °C

2: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 18 h / 85 °C

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water / 18 h / 75 °C

With sulfuric acid; sodium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In ethanol; water; toluene; 3: Suzuki Coupling;