6-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenylamino]-2-chloronicotinic acid methyl ester

Base Information

Chemical Name:6-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenylamino]-2-chloronicotinic acid methyl ester
CAS No.:1380281-68-4
Molecular Formula:C₂₂H₂₃ClN₄O₂
Molecular Weight:410.903
Hs Code.:

Synonyms:6-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenylamino]-2-chloronicotinic acid methyl ester

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Chemical Property of 6-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenylamino]-2-chloronicotinic acid methyl ester

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Technology Process of 6-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenylamino]-2-chloronicotinic acid methyl ester

There total 8 articles about 6-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenylamino]-2-chloronicotinic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1380281-65-1
5-(2-tert-butyl-pyrimidin-4-yl)-2-methylphenylamine

: 65515-28-8
methyl 2,6-dichloronicotinate

: 1380281-68-4
6-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenylamino]-2-chloronicotinic acid methyl ester

Guidance literature:: With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; In toluene; at 85 ℃; for 18h;

Reference yield:

: 38496-18-3
2,6-dichloropyridine-3-carboxylic acid

: 1380281-68-4
6-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenylamino]-2-chloronicotinic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / 80 °C

2: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 18 h / 85 °C

With sulfuric acid; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; In toluene;

Reference yield:

: 2458-12-0
3-amino-p-toluic acid

: 1380281-68-4
6-[5-(2-tert-Butyl-pyrimidin-4-yl)-2-methylphenylamino]-2-chloronicotinic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide / water / 18 h / 20 °C

2.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / tetrahydrofuran / 0.5 h

2.2: 48 h / 20 °C

3.1: diethyl ether; tetrahydrofuran / 20 °C / Cooling

4.1: N,N-dimethyl-formamide / 2 h / 60 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 85 °C

6.1: hydrogenchloride / 1,4-dioxane / 18 h

7.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / toluene / 18 h / 85 °C

With 4-methyl-morpholine; hydrogenchloride; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium hydroxide; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; water; N,N-dimethyl-formamide; toluene;