N-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]acetyl-isonipecotic acid

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Chemical Name:N-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]acetyl-isonipecotic acid
CAS No.:1357390-49-8
Molecular Formula:C₂₃H₂₇N₃O₆S
Molecular Weight:473.55
Hs Code.:

Synonyms:N-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]acetyl-isonipecotic acid

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Chemical Property of N-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]acetyl-isonipecotic acid

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Technology Process of N-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]acetyl-isonipecotic acid

There total 2 articles about N-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]acetyl-isonipecotic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1357390-48-7
methyl N-[(5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl)acetyl]-isonipecotate

: 1357390-49-8
N-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]acetyl-isonipecotic acid

Guidance literature:: methyl N-[(5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl)acetyl]-isonipecotate; With lithium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 1h;

In 1,4-dioxane; water; pH=Ca. 1; Acidic conditions;
DOI:10.1016/j.ejmech.2011.10.019

Reference yield:

: 2971-79-1
isonipecotic acid methyl ester

: 1341126-89-3
[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]acetic acid

: 1357390-49-8
N-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]acetyl-isonipecotic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.25 h

2.1: lithium hydroxide / 1,4-dioxane; water / 1 h / 20 °C

2.2: pH Ca_. 1 / Acidic conditions

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.10.019