(1R)-2-[({(1S)-1-[2-(methoxymethoxy)phenyl]-2,2-dimethylpropyl}amino)oxy]-1-phenylethanol

Base Information

Chemical Name:(1R)-2-[({(1S)-1-[2-(methoxymethoxy)phenyl]-2,2-dimethylpropyl}amino)oxy]-1-phenylethanol
CAS No.:757195-38-3
Molecular Formula:C₂₁H₂₉NO₄
Molecular Weight:359.466
Hs Code.:

Synonyms:(1R)-2-[({(1S)-1-[2-(methoxymethoxy)phenyl]-2,2-dimethylpropyl}amino)oxy]-1-phenylethanol

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Chemical Property of (1R)-2-[({(1S)-1-[2-(methoxymethoxy)phenyl]-2,2-dimethylpropyl}amino)oxy]-1-phenylethanol

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Technology Process of (1R)-2-[({(1S)-1-[2-(methoxymethoxy)phenyl]-2,2-dimethylpropyl}amino)oxy]-1-phenylethanol

There total 7 articles about (1R)-2-[({(1S)-1-[2-(methoxymethoxy)phenyl]-2,2-dimethylpropyl}amino)oxy]-1-phenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 757195-16-7
2-{[(2R)-2-(methoxymethoxy)-2-phenylethyl]oxy}-1H-isoindole-1,3(2H)-dione

: 757195-38-3
(1R)-2-[({(1S)-1-[2-(methoxymethoxy)phenyl]-2,2-dimethylpropyl}amino)oxy]-1-phenylethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: conc. HCl / methanol / 0.5 h / 20 °C

1.2: 99 percent / hydrazine hydrate / ethanol / 1 h / Heating

2.1: 99 percent / TsOH / toluene / 0.5 h / Heating

3.1: toluene; diethyl ether / 0.42 h / -20 °C

With hydrogenchloride; toluene-4-sulfonic acid; In methanol; diethyl ether; toluene;
DOI:10.1021/jo049517+

Reference yield:

: 5533-04-0
2-(methoxymethoxy)benzaldehyde

: 757195-38-3
(1R)-2-[({(1S)-1-[2-(methoxymethoxy)phenyl]-2,2-dimethylpropyl}amino)oxy]-1-phenylethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / TsOH / toluene / 0.5 h / Heating

2: toluene; diethyl ether / 0.42 h / -20 °C

With toluene-4-sulfonic acid; In diethyl ether; toluene;
DOI:10.1021/jo049517+

Reference yield:

: 20698-91-3
(R)-methyl mandelate

: 757195-38-3
(1R)-2-[({(1S)-1-[2-(methoxymethoxy)phenyl]-2,2-dimethylpropyl}amino)oxy]-1-phenylethanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 91 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 48 h / 20 °C

2.1: 99 percent / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

3.1: 99 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 9 h / 20 °C

4.1: conc. HCl / methanol / 0.5 h / 20 °C

4.2: 99 percent / hydrazine hydrate / ethanol / 1 h / Heating

5.1: 99 percent / TsOH / toluene / 0.5 h / Heating

6.1: toluene; diethyl ether / 0.42 h / -20 °C

With hydrogenchloride; lithium aluminium tetrahydride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene; 3.1: Mitsunobu reaction;
DOI:10.1021/jo049517+