Technology Process of (2S)-2-phenyl-2-({[(1R)-1-phenyl-2-propenyl]amino}oxy)ethanol
There total 23 articles about (2S)-2-phenyl-2-({[(1R)-1-phenyl-2-propenyl]amino}oxy)ethanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
cyclohexane; toluene;
at 0 ℃;
for 0.5h;
DOI:10.1021/jo049517+
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 97 percent / NaBH4 / methanol / 0.5 h / 20 °C
2: 81 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 48 h / 20 °C
3: 99 percent / hydrazine hydrate / ethanol / 1 h / Heating
4: 97 percent / TsOH / toluene / 0.5 h / Heating
5: 66 percent / toluene; cyclohexane / 0.5 h / 0 °C
With
sodium tetrahydroborate; toluene-4-sulfonic acid; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; ethanol; cyclohexane; toluene;
2: Mitsunobu reaction;
DOI:10.1021/jo049517+
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: conc. HCl / methanol / 0.5 h / 20 °C
1.2: 99 percent / hydrazine hydrate / ethanol / 1 h / Heating
2.1: 99 percent / TsOH / toluene / 0.5 h / Heating
3.1: 60 percent / toluene; diethyl ether / 0.42 h / -20 °C
4.1: Mo(CO)6 / acetonitrile; H2O / 1 h / 85 °C
5.1: 81 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 48 h / 20 °C
6.1: 99 percent / hydrazine hydrate / ethanol / 1 h / Heating
7.1: 97 percent / TsOH / toluene / 0.5 h / Heating
8.1: 66 percent / toluene; cyclohexane / 0.5 h / 0 °C
With
hydrogenchloride; hexacarbonyl molybdenum; toluene-4-sulfonic acid; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; cyclohexane; water; toluene; acetonitrile;
5.1: Mitsunobu reaction;
DOI:10.1021/jo049517+