(R)-1-(4-((2-(5-((4-(2-(tert-butyldimethylsilyloxy)ethyl)-3-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)-3-fluorophenyl)-3-cyclopropylurea

Base Information

Chemical Name:(R)-1-(4-((2-(5-((4-(2-(tert-butyldimethylsilyloxy)ethyl)-3-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)-3-fluorophenyl)-3-cyclopropylurea
CAS No.:1429397-35-2
Molecular Formula:C₃₆H₄₇FN₆O₃SSi
Molecular Weight:690.957
Hs Code.:

(R)-1-(4-((2-(5-((4-(2-(tert-butyldimethylsilyloxy)ethyl)-3-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)-3-fluorophenyl)-3-cyclopropylurea

Synonyms:(R)-1-(4-((2-(5-((4-(2-(tert-butyldimethylsilyloxy)ethyl)-3-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)-3-fluorophenyl)-3-cyclopropylurea

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Chemical Property of (R)-1-(4-((2-(5-((4-(2-(tert-butyldimethylsilyloxy)ethyl)-3-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)-3-fluorophenyl)-3-cyclopropylurea

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Technology Process of (R)-1-(4-((2-(5-((4-(2-(tert-butyldimethylsilyloxy)ethyl)-3-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)-3-fluorophenyl)-3-cyclopropylurea

There total 4 articles about (R)-1-(4-((2-(5-((4-(2-(tert-butyldimethylsilyloxy)ethyl)-3-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)-3-fluorophenyl)-3-cyclopropylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1429397-34-1
(R)-1-cyclopropyl-3-(3-fluoro-4-((2-(5-((3-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)urea

: 86864-60-0
2-(tert-butyldimethylsilyloxy)ethyl bromide

: 1429397-35-2
(R)-1-(4-((2-(5-((4-(2-(tert-butyldimethylsilyloxy)ethyl)-3-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)-3-fluorophenyl)-3-cyclopropylurea

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 65 - 70 ℃; for 4.5h; Inert atmosphere;

Reference yield:

: 170033-47-3
(R)-tert-butyl 2-methylpiperazine-1-carboxylate

: 1429397-35-2
(R)-1-(4-((2-(5-((4-(2-(tert-butyldimethylsilyloxy)ethyl)-3-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)-3-fluorophenyl)-3-cyclopropylurea

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; sodium tris(acetoxy)borohydride / 1-methyl-pyrrolidin-2-one / 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 4.5 h / 65 - 70 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1429397-33-0
(R)-tert-butyl 4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)-2-methylpiperazine-1-carboxylate

: 1429397-35-2
(R)-1-(4-((2-(5-((4-(2-(tert-butyldimethylsilyloxy)ethyl)-3-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)-3-fluorophenyl)-3-cyclopropylurea

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 4.5 h / 65 - 70 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide;