(R)-1-cyclopropyl-3-(3-fluoro-4-((2-(5-((4-(2-hydroxyethyl)-3-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)urea

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Chemical Name:(R)-1-cyclopropyl-3-(3-fluoro-4-((2-(5-((4-(2-hydroxyethyl)-3-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)urea
CAS No.:1429397-26-1
Molecular Formula:C₃₀H₃₃FN₆O₃S
Molecular Weight:576.695
Hs Code.:

Synonyms:(R)-1-cyclopropyl-3-(3-fluoro-4-((2-(5-((4-(2-hydroxyethyl)-3-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)urea

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Chemical Property of (R)-1-cyclopropyl-3-(3-fluoro-4-((2-(5-((4-(2-hydroxyethyl)-3-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)urea

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Technology Process of (R)-1-cyclopropyl-3-(3-fluoro-4-((2-(5-((4-(2-hydroxyethyl)-3-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)urea

There total 5 articles about (R)-1-cyclopropyl-3-(3-fluoro-4-((2-(5-((4-(2-hydroxyethyl)-3-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1429397-35-2
(R)-1-(4-((2-(5-((4-(2-(tert-butyldimethylsilyloxy)ethyl)-3-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)-3-fluorophenyl)-3-cyclopropylurea

: 1429397-26-1
(R)-1-cyclopropyl-3-(3-fluoro-4-((2-(5-((4-(2-hydroxyethyl)-3-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)urea

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 4h;

Reference yield:

: 1187213-95-1
1-cyclopropyl-3-(3-fluoro-4-(2-(5-formylpyridin-2-yl)thieno[3,2-b]-pyridin-7-yloxy)phenyl)urea

: 1429397-26-1
(R)-1-cyclopropyl-3-(3-fluoro-4-((2-(5-((4-(2-hydroxyethyl)-3-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid; sodium tris(acetoxy)borohydride / 1-methyl-pyrrolidin-2-one / 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 4.5 h / 65 - 70 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C

With tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 170033-47-3
(R)-tert-butyl 2-methylpiperazine-1-carboxylate

: 1429397-26-1
(R)-1-cyclopropyl-3-(3-fluoro-4-((2-(5-((4-(2-hydroxyethyl)-3-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid; sodium tris(acetoxy)borohydride / 1-methyl-pyrrolidin-2-one / 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 4.5 h / 65 - 70 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C

With tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; dimethyl sulfoxide;