4-[4-hydroxy-4'-(tetrahydro-pyran-2-yloxy)-biphenyl-2-ylmethyl]-[1,3]dioxolan-2-one

Base Information

Chemical Name:4-[4-hydroxy-4'-(tetrahydro-pyran-2-yloxy)-biphenyl-2-ylmethyl]-[1,3]dioxolan-2-one
CAS No.:1355484-35-3
Molecular Formula:C₂₁H₂₂O₆
Molecular Weight:370.402
Hs Code.:

Synonyms:4-[4-hydroxy-4'-(tetrahydro-pyran-2-yloxy)-biphenyl-2-ylmethyl]-[1,3]dioxolan-2-one

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Chemical Property of 4-[4-hydroxy-4'-(tetrahydro-pyran-2-yloxy)-biphenyl-2-ylmethyl]-[1,3]dioxolan-2-one

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Technology Process of 4-[4-hydroxy-4'-(tetrahydro-pyran-2-yloxy)-biphenyl-2-ylmethyl]-[1,3]dioxolan-2-one

There total 6 articles about 4-[4-hydroxy-4'-(tetrahydro-pyran-2-yloxy)-biphenyl-2-ylmethyl]-[1,3]dioxolan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 889865-38-7
4,4,5,5-tetramethyl-2-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)-1,3,2-dioxaborolan

: 1355484-33-1
4-(2-bromo-5-hydroxy-benzyl)-[1,3]dioxolan-2-one

: 1355484-35-3
4-[4-hydroxy-4'-(tetrahydro-pyran-2-yloxy)-biphenyl-2-ylmethyl]-[1,3]dioxolan-2-one

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,2-dimethoxyethane; at 50 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.11.030

Reference yield:

: 1355484-68-2
C₁₀H₁₃BrO₃

: 1355484-35-3
4-[4-hydroxy-4'-(tetrahydro-pyran-2-yloxy)-biphenyl-2-ylmethyl]-[1,3]dioxolan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / dichloromethane / -78 °C

1.2: 0.5 h / 20 °C

2.1: boron tribromide / dichloromethane / 40 h / 20 °C / Inert atmosphere

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,2-dimethoxyethane / 2 h / 50 °C / Inert atmosphere

With pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; boron tribromide; sodium carbonate; In 1,2-dimethoxyethane; dichloromethane;
DOI:10.1016/j.bmcl.2011.11.030

Reference yield:

: 17131-19-0
3-(3-methoxy-phenyl)-propane-1,2-diol

: 1355484-35-3
4-[4-hydroxy-4'-(tetrahydro-pyran-2-yloxy)-biphenyl-2-ylmethyl]-[1,3]dioxolan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / acetone / 5.5 h / 20 °C / Inert atmosphere

1.2: 18 h / 20 °C / Inert atmosphere

2.1: hydrogenchloride; water / methanol / 5 h / 20 °C

3.1: pyridine / dichloromethane / -78 °C

3.2: 0.5 h / 20 °C

4.1: boron tribromide / dichloromethane / 40 h / 20 °C / Inert atmosphere

5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,2-dimethoxyethane / 2 h / 50 °C / Inert atmosphere

With pyridine; hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; boron tribromide; sodium carbonate; toluene-4-sulfonic acid; In methanol; 1,2-dimethoxyethane; dichloromethane; acetone;
DOI:10.1016/j.bmcl.2011.11.030