Technology Process of 1-benzyloxy-2,4,5,8-tetramethoxynaphthalene
There total 8 articles about 1-benzyloxy-2,4,5,8-tetramethoxynaphthalene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1,2-dibromo-3-benzyloxy-4,6-dimethoxybenzene; 2-methoxyfuran;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 3.5h;
Inert atmosphere;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 0 ℃;
for 1h;
Inert atmosphere;
methyl iodide;
In
tetrahydrofuran; mineral oil;
at 0 - 20 ℃;
Inert atmosphere;
DOI:10.1039/c9ob01221d
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 90 percent / bromine; acetic acid; sodium acetate / 0.25 h / 25 °C
2.1: n-butyllithium / tetrahydrofuran / -78 - 25 °C
2.2: 42 percent / potassium carbonate / acetone / 48 h / Heating
With
n-butyllithium; bromine; sodium acetate; acetic acid;
In
tetrahydrofuran;
DOI:10.1080/00397910600616693
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 90 percent / potassium carbonate / dimethylformamide / 5 h / 80 °C
2.1: m-chloroperbenzoic acid / CH2Cl2 / 4 h / Heating
3.1: 12.4 g / potassium hydroxide / H2O / 18 h / 25 °C
4.1: 78 percent / potassium carbonate / acetone / 18 h / Heating
5.1: 90 percent / bromine; acetic acid; sodium acetate / 0.25 h / 25 °C
6.1: n-butyllithium / tetrahydrofuran / -78 - 25 °C
6.2: 42 percent / potassium carbonate / acetone / 48 h / Heating
With
potassium hydroxide; n-butyllithium; bromine; sodium acetate; potassium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone;
2.1: Baeyer-Villiger oxidation;
DOI:10.1080/00397910600616693
