1,1-dimethylethyl [2-({[4-hydroxy-3-(trifluoromethyl)phenyl]carbonyl}amino)-3-phenylpropyl]carbamate

Base Information

Chemical Name:1,1-dimethylethyl [2-({[4-hydroxy-3-(trifluoromethyl)phenyl]carbonyl}amino)-3-phenylpropyl]carbamate
CAS No.:1067612-44-5
Molecular Formula:C₂₂H₂₅F₃N₂O₄
Molecular Weight:438.447
Hs Code.:

Synonyms:1,1-dimethylethyl [2-({[4-hydroxy-3-(trifluoromethyl)phenyl]carbonyl}amino)-3-phenylpropyl]carbamate

Suppliers and Price of 1,1-dimethylethyl [2-({[4-hydroxy-3-(trifluoromethyl)phenyl]carbonyl}amino)-3-phenylpropyl]carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,1-dimethylethyl [2-({[4-hydroxy-3-(trifluoromethyl)phenyl]carbonyl}amino)-3-phenylpropyl]carbamate

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Technology Process of 1,1-dimethylethyl [2-({[4-hydroxy-3-(trifluoromethyl)phenyl]carbonyl}amino)-3-phenylpropyl]carbamate

There total 1 articles about 1,1-dimethylethyl [2-({[4-hydroxy-3-(trifluoromethyl)phenyl]carbonyl}amino)-3-phenylpropyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 220239-68-9
4-hydroxy-3-(trifluoromethyl)benzoic acid

: 943323-35-1,400652-57-5
tert-butyl (2-amino-3-phenylpropyl)carbamate

: 1067612-44-5
1,1-dimethylethyl [2-({[4-hydroxy-3-(trifluoromethyl)phenyl]carbonyl}amino)-3-phenylpropyl]carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; for 12h;

Reference yield: 43.0%

: 456-64-4
phenyl trifluoromethanesulfonamide

: 1067612-44-5
1,1-dimethylethyl [2-({[4-hydroxy-3-(trifluoromethyl)phenyl]carbonyl}amino)-3-phenylpropyl]carbamate

: 1067612-47-8
4-({[2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-1-(phenylmethyl)ethyl]amino}carbonyl)-2-(trifluoromethyl)phenyl trifluoromethanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

: 1067612-44-5
1,1-dimethylethyl [2-({[4-hydroxy-3-(trifluoromethyl)phenyl]carbonyl}amino)-3-phenylpropyl]carbamate

: 1067612-50-3
1,1-dimethylethyl [2-({[4-(1-methyl-1H-pyrazol-5-yl)-3-(trifluoromethyl)phenyl]carbonyl}amino)-3-phenylpropyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 24 h / 20 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 12 h / 80 °C / Sealed tube

With potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water;