tert-butyl (7R,7aR)-3-(hydroxymethyl)-6-oxo-7-[(2-phenylacetyl)amino]-7,7a-dihydro-2H,6H-azeto[2,1-b][1,3]thiazine-4-carboxylate

Base Information

Chemical Name:tert-butyl (7R,7aR)-3-(hydroxymethyl)-6-oxo-7-[(2-phenylacetyl)amino]-7,7a-dihydro-2H,6H-azeto[2,1-b][1,3]thiazine-4-carboxylate
CAS No.:362673-18-5
Molecular Formula:C₂₀H₂₄N₂O₅S
Molecular Weight:404.487
Hs Code.:

Synonyms:tert-butyl (7R,7aR)-3-(hydroxymethyl)-6-oxo-7-[(2-phenylacetyl)amino]-7,7a-dihydro-2H,6H-azeto[2,1-b][1,3]thiazine-4-carboxylate

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Chemical Property of tert-butyl (7R,7aR)-3-(hydroxymethyl)-6-oxo-7-[(2-phenylacetyl)amino]-7,7a-dihydro-2H,6H-azeto[2,1-b][1,3]thiazine-4-carboxylate

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Technology Process of tert-butyl (7R,7aR)-3-(hydroxymethyl)-6-oxo-7-[(2-phenylacetyl)amino]-7,7a-dihydro-2H,6H-azeto[2,1-b][1,3]thiazine-4-carboxylate

There total 8 articles about tert-butyl (7R,7aR)-3-(hydroxymethyl)-6-oxo-7-[(2-phenylacetyl)amino]-7,7a-dihydro-2H,6H-azeto[2,1-b][1,3]thiazine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 53638-83-8
(6R,7R)-tert-butyl 3-(acetoxymethyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

: 362673-18-5
tert-butyl (7R,7aR)-3-(hydroxymethyl)-6-oxo-7-[(2-phenylacetyl)amino]-7,7a-dihydro-2H,6H-azeto[2,1-b][1,3]thiazine-4-carboxylate

Guidance literature:: With Candida antarctica lipase B; In tetrahydrofuran; hexane; iso-butanol; at 50 ℃; for 96h; Molecular sieve; Enzymatic reaction;
DOI:10.1021/jo902406b

Reference yield: 94.0%

: C₂₁H₂₄N₂O₆S

: 362673-18-5
tert-butyl (7R,7aR)-3-(hydroxymethyl)-6-oxo-7-[(2-phenylacetyl)amino]-7,7a-dihydro-2H,6H-azeto[2,1-b][1,3]thiazine-4-carboxylate

Guidance literature:: With Candida antarctica lipase B; In tetrahydrofuran; hexane; butan-1-ol; at 50 ℃; for 120h; Catalytic behavior; Molecular sieve;
DOI:10.1016/j.bmcl.2016.02.076

Reference yield:

: 28240-15-5
3-hydroxymethyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

: 75-65-0
tert-butyl alcohol

: 362673-18-5
tert-butyl (7R,7aR)-3-(hydroxymethyl)-6-oxo-7-[(2-phenylacetyl)amino]-7,7a-dihydro-2H,6H-azeto[2,1-b][1,3]thiazine-4-carboxylate

Guidance literature:: With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 20 ℃; for 17h;
DOI:10.1002/1099-0690(200107)2001:13<2529::AID-EJOC2529>3.0.CO;2-9