Benzyloxycarbonyl-L-prolyl-leucyl-α-aminoisobutyryl-α-aminoisobutyric acid tert-butyl ester

Base Information

Chemical Name:Benzyloxycarbonyl-L-prolyl-leucyl-α-aminoisobutyryl-α-aminoisobutyric acid tert-butyl ester
CAS No.:83537-96-6
Molecular Formula:C₃₁H₄₈N₄O₇
Molecular Weight:588.745
Hs Code.:

Synonyms:Benzyloxycarbonyl-L-prolyl-leucyl-α-aminoisobutyryl-α-aminoisobutyric acid tert-butyl ester

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Chemical Property of Benzyloxycarbonyl-L-prolyl-leucyl-α-aminoisobutyryl-α-aminoisobutyric acid tert-butyl ester

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Technology Process of Benzyloxycarbonyl-L-prolyl-leucyl-α-aminoisobutyryl-α-aminoisobutyric acid tert-butyl ester

There total 4 articles about Benzyloxycarbonyl-L-prolyl-leucyl-α-aminoisobutyryl-α-aminoisobutyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4512-32-7
H-Aib-OtBu

: 83537-96-6
Benzyloxycarbonyl-L-prolyl-leucyl-α-aminoisobutyryl-α-aminoisobutyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / toluene / 1) 4h, 60 deg C, 2) 16h, room temp.

2: 92 percent / H₂ / Pd(10percent on charcoal) / methanol / 5 h

3: 1) N-methylmorpholine, isobutyl chloroformate / 1) CH₂Cl₂, -15 deg C, 15 min, 2) CH₂Cl₂, from -15 deg C to room temp., 18h

With 4-methyl-morpholine; hydrogen; isobutyl chloroformate; 10% palladium on active carbon; In methanol; toluene;
DOI:10.1002/jlac.198219820909

Reference yield:

: 4512-31-6
benzyloxycarbonyl-α-aminoisobutyric acid tert-butyl ester

: 83537-96-6
Benzyloxycarbonyl-L-prolyl-leucyl-α-aminoisobutyryl-α-aminoisobutyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂

2: 75 percent / toluene / 1) 4h, 60 deg C, 2) 16h, room temp.

3: 92 percent / H₂ / Pd(10percent on charcoal) / methanol / 5 h

4: 1) N-methylmorpholine, isobutyl chloroformate / 1) CH₂Cl₂, -15 deg C, 15 min, 2) CH₂Cl₂, from -15 deg C to room temp., 18h

With 4-methyl-morpholine; hydrogen; isobutyl chloroformate; 10% palladium on active carbon; In methanol; toluene;
DOI:10.1002/jlac.198219820909

Reference yield:

: 83537-94-4
Benzyloxycarbonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert butyl ester

: 83537-96-6
Benzyloxycarbonyl-L-prolyl-leucyl-α-aminoisobutyryl-α-aminoisobutyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / H₂ / Pd(10percent on charcoal) / methanol / 5 h

2: 1) N-methylmorpholine, isobutyl chloroformate / 1) CH₂Cl₂, -15 deg C, 15 min, 2) CH₂Cl₂, from -15 deg C to room temp., 18h

With 4-methyl-morpholine; hydrogen; isobutyl chloroformate; 10% palladium on active carbon; In methanol;
DOI:10.1002/jlac.198219820909