S-(2-{[(benzyloxy)carbonyl]amino}-1-phenylethyl) ethanethioate

Base Information

Chemical Name:S-(2-{[(benzyloxy)carbonyl]amino}-1-phenylethyl) ethanethioate
CAS No.:883907-24-2
Molecular Formula:C₁₈H₁₉NO₃S
Molecular Weight:329.42
Hs Code.:
Mol file:883907-24-2.mol

Synonyms:(S)-2-(benzyloxycarbonyl)amino-1-phenylethyl thioacetate

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Chemical Property of S-(2-{[(benzyloxy)carbonyl]amino}-1-phenylethyl) ethanethioate

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Technology Process of S-(2-{[(benzyloxy)carbonyl]amino}-1-phenylethyl) ethanethioate

There total 3 articles about S-(2-{[(benzyloxy)carbonyl]amino}-1-phenylethyl) ethanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 144372-50-9
(R)-benzyl N-(2-hydroxy-2-phenylethyl)carbamate

: 507-09-5
tiolacetic acid

: 883907-24-2
(S)-2-(benzyloxycarbonyl)amino-1-phenylethyl thioacetate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at -10 - 20 ℃; for 21h;
DOI:10.1002/hc.20133

Reference yield:

: 2549-14-6,1936-63-6
(R)-2-Amino-1-phenylethanol

: 883907-24-2
(S)-2-(benzyloxycarbonyl)amino-1-phenylethyl thioacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / NaOH / CH₂Cl₂; toluene / 20 °C

2: 63 percent / diethyl azodicarboxylate; Ph₃P / tetrahydrofuran / 21 h / -10 - 20 °C

With sodium hydroxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; toluene; 2: Mitsunobu displacement reaction;
DOI:10.1002/hc.20133

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 883907-24-2
(S)-2-(benzyloxycarbonyl)amino-1-phenylethyl thioacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / NaOH / CH₂Cl₂; toluene / 20 °C

2: 63 percent / diethyl azodicarboxylate; Ph₃P / tetrahydrofuran / 21 h / -10 - 20 °C

With sodium hydroxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; toluene; 2: Mitsunobu displacement reaction;
DOI:10.1002/hc.20133