N-[(1S,2R)-2-[1-(4-fluorophenyl)indazol-5-yl]oxy-2-(3-methoxyphenyl)-1-methyl-ethyl]-4-nitro-benzenesulfonamide

Base Information

Chemical Name:N-[(1S,2R)-2-[1-(4-fluorophenyl)indazol-5-yl]oxy-2-(3-methoxyphenyl)-1-methyl-ethyl]-4-nitro-benzenesulfonamide
CAS No.:1417334-59-8
Molecular Formula:C₂₉H₂₅FN₄O₆S
Molecular Weight:576.605
Hs Code.:

Synonyms:N-[(1S,2R)-2-[1-(4-fluorophenyl)indazol-5-yl]oxy-2-(3-methoxyphenyl)-1-methyl-ethyl]-4-nitro-benzenesulfonamide

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Chemical Property of N-[(1S,2R)-2-[1-(4-fluorophenyl)indazol-5-yl]oxy-2-(3-methoxyphenyl)-1-methyl-ethyl]-4-nitro-benzenesulfonamide

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Technology Process of N-[(1S,2R)-2-[1-(4-fluorophenyl)indazol-5-yl]oxy-2-(3-methoxyphenyl)-1-methyl-ethyl]-4-nitro-benzenesulfonamide

There total 3 articles about N-[(1S,2R)-2-[1-(4-fluorophenyl)indazol-5-yl]oxy-2-(3-methoxyphenyl)-1-methyl-ethyl]-4-nitro-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1417334-60-1
N-[(1S,2R)-2-hydroxy-2-(3-methoxyphenyl)-1-methyl-ethyl]-4-nitro-benzene sulfonamide

: 1417334-59-8
N-[(1S,2R)-2-[1-(4-fluorophenyl)indazol-5-yl]oxy-2-(3-methoxyphenyl)-1-methyl-ethyl]-4-nitro-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 2-methyltetrahydrofuran / 16.16 h / 40 °C / Industrial scale

2: hydrogenchloride / water / Industrial scale

3: 17 h / 40 °C / Industrial scale

With hydrogenchloride; In 2-methyltetrahydrofuran; water;

Reference yield:

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 1417334-59-8
N-[(1S,2R)-2-[1-(4-fluorophenyl)indazol-5-yl]oxy-2-(3-methoxyphenyl)-1-methyl-ethyl]-4-nitro-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 4-methyl-morpholine / 2-methyltetrahydrofuran / 1.5 h / 40 °C / Industrial scale

2: 2-methyltetrahydrofuran / 16.16 h / 40 °C / Industrial scale

3: hydrogenchloride / water / Industrial scale

4: 17 h / 40 °C / Industrial scale

With 4-methyl-morpholine; hydrogenchloride; In 2-methyltetrahydrofuran; water;

Reference yield:

: 352-33-0
1-Chloro-4-fluorobenzene

: 15579-15-4
5-hydroxy-1H-indazole

: 1417334-59-8
N-[(1S,2R)-2-[1-(4-fluorophenyl)indazol-5-yl]oxy-2-(3-methoxyphenyl)-1-methyl-ethyl]-4-nitro-benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; tert-butyl XPhos / 2-methyltetrahydrofuran / 15 h / 73 °C / Industrial scale

2: 17 h / 40 °C / Industrial scale

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; tert-butyl XPhos; In 2-methyltetrahydrofuran;