Technology Process of 2-<8-(tert-butoxycarbonyl)-5-oxo-7-phenyl-4,8-diazaoctyl>-4-(formylmethyl)-1,2,3,4-tetrahydroisoquinolin-1-one
There total 12 articles about 2-<8-(tert-butoxycarbonyl)-5-oxo-7-phenyl-4,8-diazaoctyl>-4-(formylmethyl)-1,2,3,4-tetrahydroisoquinolin-1-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridinium chlorochromate;
In
dichloromethane;
for 2h;
Ambient temperature;
DOI:10.1021/jo00374a035
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 75 percent / sodium acetate / ethanol / 2 h / Heating
2: 90 percent / 2 h / 100 °C
3: 95 percent / KMnO4, H2O / acetone / 1 h / Ambient temperature
4: 95 percent / H2 / platinum oxide / CHCl3; ethanol / 8 h / 20 °C / 760 Torr
5: 86 percent / 1-methyl-2-chloropyridinium iodide, triethylamine / CH2Cl2 / 2 h / Ambient temperature
6: 90 percent / K2CO3 / methanol / 2 h / Ambient temperature
7: 75 percent / pyridinium chlorochromate / CH2Cl2 / 2 h / Ambient temperature
With
potassium permanganate; 2-chloro-1-methyl-pyridinium iodide; water; hydrogen; sodium acetate; potassium carbonate; triethylamine; pyridinium chlorochromate;
platinum(IV) oxide;
In
methanol; ethanol; dichloromethane; chloroform; acetone;
DOI:10.1021/jo00374a035
- Guidance literature:
-
Multi-step reaction with 8 steps
1: concd. hydrochloric acid, H2 / 20percent Pd/C / methanol / 24 h / 20 °C / 760 Torr
2: 75 percent / sodium acetate / ethanol / 2 h / Heating
3: 90 percent / 2 h / 100 °C
4: 95 percent / KMnO4, H2O / acetone / 1 h / Ambient temperature
5: 95 percent / H2 / platinum oxide / CHCl3; ethanol / 8 h / 20 °C / 760 Torr
6: 86 percent / 1-methyl-2-chloropyridinium iodide, triethylamine / CH2Cl2 / 2 h / Ambient temperature
7: 90 percent / K2CO3 / methanol / 2 h / Ambient temperature
8: 75 percent / pyridinium chlorochromate / CH2Cl2 / 2 h / Ambient temperature
With
hydrogenchloride; potassium permanganate; 2-chloro-1-methyl-pyridinium iodide; water; hydrogen; sodium acetate; potassium carbonate; triethylamine; pyridinium chlorochromate;
platinum(IV) oxide; palladium on activated charcoal;
In
methanol; ethanol; dichloromethane; chloroform; acetone;
DOI:10.1021/jo00374a035
