Technology Process of Boc-Ala-Gly-Pro-Ile-NHBn
There total 3 articles about Boc-Ala-Gly-Pro-Ile-NHBn which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Boc-Ala-Gly-Pro-OBn;
With
hydrogen;
palladium on activated charcoal;
In
methanol;
at 20 ℃;
for 1h;
under 3000.3 Torr;
(2S,3S)-2-amino-N-benzyl-3-methylpentanamide;
With
benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide;
4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;
at 20 ℃;
Further stages.;
DOI:10.1021/jm9903139
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: DCM; TFA
1.2: 92 percent / DCC; HOBT; DIPEA/DCM
2.1: H2 / Pd-C / methanol / 1 h / 20 °C / 3000.3 Torr
2.2: 80 percent / DIEA; HOBT; DCC / DCM / 20 °C
With
hydrogen; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; trifluoroacetic acid;
palladium on activated charcoal;
In
methanol;
1.1: Catalytic hydrogenation / 1.2: Substitution / 2.1: Catalytic hydrogenation / 2.2: Substitution;
DOI:10.1021/jm9903139
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 90 percent / HCl; DCC; HOBT / DIPEA/DCM
2.1: DCM; TFA
2.2: 92 percent / DCC; HOBT; DIPEA/DCM
3.1: H2 / Pd-C / methanol / 1 h / 20 °C / 3000.3 Torr
3.2: 80 percent / DIEA; HOBT; DCC / DCM / 20 °C
With
hydrogenchloride; hydrogen; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid;
palladium on activated charcoal; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; N-ethyl-N,N-diisopropylamine;
In
methanol;
1.1: Substitution / 2.1: Catalytic hydrogenation / 2.2: Substitution / 3.1: Catalytic hydrogenation / 3.2: Substitution;
DOI:10.1021/jm9903139
