6-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-6-(4-methyl-benzylamino)-hexanoic acid

Base Information

Chemical Name:6-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-6-(4-methyl-benzylamino)-hexanoic acid
CAS No.:244161-54-4
Molecular Formula:C₂₂H₂₉NO₄
Molecular Weight:371.477
Hs Code.:

Synonyms:6-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-6-(4-methyl-benzylamino)-hexanoic acid

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Chemical Property of 6-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-6-(4-methyl-benzylamino)-hexanoic acid

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Technology Process of 6-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-6-(4-methyl-benzylamino)-hexanoic acid

There total 2 articles about 6-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-6-(4-methyl-benzylamino)-hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 204510-98-5
6-hydroxy-6-(4,4-Dimethyl-2,6-dioxocyclo-hexylidene)-hexanoic Acid

: 104-84-7
para-methylbenzylamine

: 244161-54-4
6-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-6-(4-methyl-benzylamino)-hexanoic acid

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 7h;
DOI:10.1016/S0040-4039(99)01042-4

Reference yield:

: 244161-53-3
6-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-6-hydroxy-hexanoic acid ethyl ester

: 244161-54-4
6-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-6-(4-methyl-benzylamino)-hexanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / NaOH / H₂O; tetrahydrofuran / 5 h / 20 °C

2: 97 percent / DIPEA / CH₂Cl₂ / 7 h / 20 °C

With sodium hydroxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; 1: Hydrolysis / 2: Condensation;
DOI:10.1016/S0040-4039(99)01042-4

Reference yield:

: N-(tert-butoxycarbonyl)-N-(α-dideutero)benzyldiaminoethane

: 244161-54-4
6-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-6-(4-methyl-benzylamino)-hexanoic acid

: C₃₁H₃₉⁽²⁾H₂N₃O₃

Guidance literature:: N-(tert-butoxycarbonyl)-N-(α-dideutero)benzyldiaminoethane; With aminomethyl ArgoGel^TM resin; sodium tris(acetoxy)borohydride; acetic acid; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

6-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-6-(4-methyl-benzylamino)-hexanoic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; for 16h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1016/S0040-4039(99)01042-4